Novel HDAC6 inhibitors increase tubulin acetylation and rescue axonal transport of mitochondria in a model of Charcot-Marie-Tooth Type 2F.
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DOI: 10.1021/acschemneuro.9b00338
Abstract: Disruption of axonal transport causes a number of rare, inherited axonopathies and is heavily implicated in a wide range of more common neurodegenerative disorders, many of them age-related. Acetylation of α-tubulin is one important regulatory… read more here.
Keywords: acetylation; hdac6 inhibitors; rescue axonal; transport ... See more keywords