Meridianins Rescue Cognitive Deficits, Spine Density and Neuroinflammation in the 5xFAD Model of Alzheimer’s Disease
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.791666
Abstract: Glycogen synthase kinase 3β (GSK3β) is a core protein, with a relevant role in many neurodegenerative disorders including Alzheimer’s disease. The enzyme has been largely studied as a potential therapeutic target for several neurological diseases.… read more here.
Keywords: model alzheimer; disease; alzheimer disease; meridianins rescue ... See more keywords
Low-Affinity/High-Selectivity Dopamine Transport Inhibition Sufficient to Rescue Cognitive Functions in the Aging Rat
Sign Up to like & getrecommendations! Published in 2023 at "Biomolecules"
DOI: 10.3390/biom13030467
Abstract: The worldwide increase in cognitive decline, both in aging and with psychiatric disorders, warrants a search for pharmacological treatment. Although dopaminergic treatment approaches represent a major step forward, current dopamine transporter (DAT) inhibitors are not… read more here.
Keywords: cognitive functions; rescue cognitive; low affinity; dopamine ... See more keywords
Rescue of cognitive function following fractionated brain irradiation in a novel preclinical glioma model
Sign Up to like & getrecommendations! Published in 2018 at "eLife"
DOI: 10.7554/elife.38865
Abstract: More than half of long-term brain tumor survivors develop irreversible cognitive decline that severely affect their quality of life. However, there is no pre-clinical model that allows long-term assessment of cognition, and there is no… read more here.
Keywords: glioma; rescue cognitive; model; brain ... See more keywords