Reduced current density, partially rescued by mexiletine, and depolarizing shift in activation of SCN5A W374G channels as a cause of severe form of Brugada syndrome
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DOI: 10.1111/anec.12828
Abstract: SCN5A‐related Brugada syndrome (BrS) can be caused by multiple mechanisms including trafficking defects and altered channel gating properties. Most SCN5A mutations at pore region cause trafficking defects, and some of them can be rescued by… read more here.
Keywords: reduced current; current density; rescued mexiletine; brugada syndrome ... See more keywords