Targeting G-quadruplexes in an ageing epigenetic regulator promoter for rescuing mitochondrial dysfunction in Alzheimer's disease.
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DOI: 10.1039/d2cc05957f
Abstract: Here, we provide an out-of-the-box G-quadruplex (G4) targeting-based strategy for rescuing mitochondrial dysfunction in Alzheimer's disease. We predict and verify the presence of G4s within the promoter of an ageing epigenetic regulator BAZ2B. G4-specific ligands… read more here.
Keywords: promoter; epigenetic regulator; mitochondrial dysfunction; dysfunction ... See more keywords