Detecting and Rescuing Stalled Ribosomes.
Sign Up to like & getrecommendations! Published in 2021 at "Trends in biochemical sciences"
DOI: 10.1016/j.tibs.2021.03.008
Abstract: Ribosomes that stall inappropriately during protein synthesis harbor proteotoxic components linked to cellular stress and neurodegenerative diseases. Molecular mechanisms that rescue stalled ribosomes must selectively detect rare aberrant translational complexes and process the heterogeneous components.… read more here.
Keywords: rescuing stalled; stalled ribosomes; detecting rescuing;
Rescuing stalled mammalian mitoribosomes – what can we learn from bacteria?
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cell Science"
DOI: 10.1242/jcs.231811
Abstract: ABSTRACT In the canonical process of translation, newly completed proteins escape from the ribosome following cleavage of the ester bond that anchors the polypeptide to the P-site tRNA, after which the ribosome can be recycled… read more here.
Keywords: mammalian mitochondria; rescue; rescuing stalled; translation ... See more keywords