Evaluation of the Association of Perioperative UGT1A1 Genotype-Dosed gFOLFIRINOX With Margin-Negative Resection Rates and Pathologic Response Grades Among Patients With Locally Advanced Gastroesophageal Adenocarcinoma: A Phase 2 Clinical Trial.
Sign Up to like & getrecommendations! Published in 2020 at "JAMA network open"
DOI: 10.1001/jamanetworkopen.2019.21290
Abstract: Importance Patients with locally advanced gastroesophageal adenocarcinoma (ie, stage ≥T3 and/or node positive) have high rates of recurrence despite surgery and adjunctive perioperative therapies, which also have high toxicity profiles. Evaluation of pharmacogenomically dosed perioperative… read more here.
Keywords: ugt1a1 genotype; genotype; gastroesophageal; patients locally ... See more keywords
Extent of Tumor Resection and Survival in Pediatric Patients With High-Grade Gliomas
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DOI: 10.1001/jamanetworkopen.2022.26551
Abstract: This systematic review and meta-analysis describes postoperative outcomes associated with gross total resection, subtotal resection, and biopsy in children with high-grade gliomas. read more here.
Keywords: high grade; grade gliomas; tumor resection; resection ... See more keywords
Laparoscopic Rectal Resection-Ready for Prime Time?
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DOI: 10.1001/jamaoncol.2016.3202
Abstract: Withthepromiseofreducedsurgicaltraumaandquickerrecovery,laparoscopic surgery has gained popularity over the past 2 decades. However, the recent publication of the Australasian Laparoscopic Cancer of the Rectum Randomized Clinical Trial (ALaCaRT)1 questions whether it is appropriate for rectal cancer. The… read more here.
Keywords: laparoscopic; ready prime; laparoscopic rectal; resection ready ... See more keywords
Association Between Pancreatic Fistula and Long-term Survival in the Era of Neoadjuvant Chemotherapy.
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DOI: 10.1001/jamasurg.2019.2272
Abstract: Importance In the past decade, the use of neoadjuvant therapy (NAT) has increased for patients with borderline and locally advanced pancreatic ductal adenocarcinoma (PDAC). Data on pancreatic fistula and related overall survival (OS) in this… read more here.
Keywords: pancreatic fistula; long term; upfront resection; survival ... See more keywords
Anterior Approach vs Conventional Hepatectomy for Resection of Colorectal Liver Metastasis: A Randomized Clinical Trial.
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DOI: 10.1001/jamasurg.2020.5050
Abstract: Importance Tumor relapse after partial hepatectomy for colorectal liver metastasis (CRLM) remains an unsolved issue. Intraoperative manipulation of the liver during conventional hepatectomy might enhance hematogenous tumor cell spread. The anterior approach is an alternative… read more here.
Keywords: conventional hepatectomy; anterior approach; resection; tumor ... See more keywords
Comparison of Hepatic Arterial Infusion Pump Chemotherapy vs Resection for Patients With Multifocal Intrahepatic Cholangiocarcinoma.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA surgery"
DOI: 10.1001/jamasurg.2022.1298
Abstract: Importance Intrahepatic cholangiocarcinoma (iCCA) is often multifocal (ie, satellites or intrahepatic metastases) at presentation. Objective To compare the overall survival (OS) of patients with multifocal iCCA after hepatic arterial infusion pump (HAIP) floxuridine chemotherapy vs… read more here.
Keywords: multifocal icca; patients multifocal; group; resection ... See more keywords
Early assessment of circulating tumor DNA after curative-intent resection predicts tumor recurrence in early-stage and locally advanced non-small cell lung cancer.
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DOI: 10.1002/1878-0261.13116
Abstract: Circulating tumor DNA (ctDNA) has demonstrated great potential as a non-invasive biomarker to assess minimal residual disease (MRD) and to profile tumor genotypes in patients with non-small cell lung cancer (NSCLC). However, little is known… read more here.
Keywords: early stage; locally advanced; stage locally; resection ... See more keywords
Temporal lobe epilepsy surgery: Piriform cortex resection impacts seizure control in the long‐term
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DOI: 10.1002/acn3.51620
Abstract: Recently, we showed that resection of at least 27% of the temporal part of piriform cortex (PiC) strongly correlated with seizure freedom 1 year following selective amygdalo‐hippocampectomy (tsSAHE) in patients with mesial temporal lobe epilepsy (mTLE).… read more here.
Keywords: long term; seizure; piriform cortex; temporal lobe ... See more keywords
Pain affect disrupted in children with posterior cerebellar tumor resection
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DOI: 10.1002/acn3.709
Abstract: Damage to the posterior cerebellum can cause affective deficits in patients. In adults, cerebellar infarcts result in thermal hyperalgesia and affect descending modulation of pain. This study evaluated the effect of resection of low‐grade cerebellar… read more here.
Keywords: pain affect; affect disrupted; pain; disrupted children ... See more keywords
Rational Design of a Self‐Assembling High Performance Organic Nanofluorophore for Intraoperative NIR‐II Image‐Guided Tumor Resection of Oral Cancer
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DOI: 10.1002/advs.202206435
Abstract: The first line of treatment for most solid tumors is surgical resection of the primary tumor with adequate negative margins. Incomplete tumor resections with positive margins account for over 75% of local recurrences and the… read more here.
Keywords: intraoperative nir; resection; tumor; image guided ... See more keywords
Surgical resection of ripple onset predicts outcome in pediatric epilepsy
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DOI: 10.1002/ana.25295
Abstract: In patients with medically refractory epilepsy (MRE), interictal ripples (80–250Hz) are observed in large brain areas whose resection may be unnecessary for seizure freedom. This limits their utility as epilepsy biomarkers for surgery. We assessed… read more here.
Keywords: epilepsy; surgical resection; resection ripple; ripple onset ... See more keywords