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Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2113535119
Abstract: Significance Preclinical studies of metastatic melanoma treated with targeted therapeutics have suggested that alternating periods of treatment and withdrawal might delay the onset of resistance. This has been attributed to drug addiction, where cells lose…
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Keywords:
drug rechallenge;
intermittent treatment;
resistance;
resensitization ... See more keywords
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Published in 2020 at "NeuroReport"
DOI: 10.1097/wnr.0000000000001485
Abstract: Transient receptor potential vanilloid type-1 (TRPV1) channels have crucial roles in inflammatory hyperalgesia. Different inflammatory mediators can modulate TRPV1 sensitization. Bradykinin is an algogenic substance released at the site of inflammation. The aim of the…
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Keywords:
bradykinin;
trpv1;
receptor;
resensitization ... See more keywords
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Published in 2020 at "Circulation Research"
DOI: 10.1161/res.127.suppl_1.425
Abstract: β adrenergic receptor (βAR) function is regulated by G-protein coupled receptor (GPCR) kinase (GRK) driven desensitization and protein phosphatase 2A (PP2A) mediated resensitization to its classical agonist. Surprisingly, Insulin modulates (βARs) function thus regulating cardiac…
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Keywords:
insulin;
pp2a activity;
pi3k;
function ... See more keywords
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Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23105320
Abstract: γ-Aminobutyric acid type A receptors (GABAARs) mediate primarily inhibitory synaptic transmission in the central nervous system. Following fast-paced activation, which provides the selective flow of mainly chloride (Cl−) and less bicarbonate (HCO3−) ions via the…
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Keywords:
desensitization;
gabaa receptor;
atpase gabaa;
resensitization ... See more keywords