Outward Movement of Targeting Ligands from a Built‐In Reserve Pool in Nuclease‐Resistant 3D Hierarchical DNA Nanocluster for in Vivo High‐Precision Cancer Therapy
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DOI: 10.1002/advs.202203698
Abstract: Nanostructures made entirely of DNAs display great potential as chemotherapeutic drug carriers but so far cannot achieve sufficient clinic therapy outcomes due to off‐target toxicity. In this contribution, an aptamer‐embedded hierarchical DNA nanocluster (Apt‐eNC) is… read more here.
Keywords: reserve pool; apt enc; therapy; dna nanocluster ... See more keywords
Intersectin associates with synapsin and regulates its nanoscale localization and function
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DOI: 10.1073/pnas.1715341114
Abstract: Significance Mutations in genes regulating neurotransmission in the brain are implicated in neurological disorders and neurodegeneration. Synapsin is a crucial regulator of neurotransmission and allows synapses to maintain a large reserve pool of synaptic vesicles.… read more here.
Keywords: function; neurotransmission; intersectin; reserve pool ... See more keywords