Tumor-reprogrammed resident T cells resist radiation to control tumors
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-11906-2
Abstract: Successful combinations of radiotherapy and immunotherapy depend on the presence of live T cells within the tumor; however, radiotherapy is believed to damage T cells. Here, based on longitudinal in vivo imaging and functional analysis,… read more here.
Keywords: tumor; resident cells; control; reprogrammed resident ... See more keywords
The embryonic node behaves as an instructive stem cell niche for axial elongation
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2108935119
Abstract: Significance Previous studies have suggested that the amniote node (Hensen’s node) contains a small population of self-renewing resident cells whose progeny progressively lay down axial tissues, including notochord and somites. This can only be demonstrated… read more here.
Keywords: cell; node; single cells; niche ... See more keywords
Brain-Resident T Cells Following Viral Infection.
Sign Up to like & getrecommendations! Published in 2019 at "Viral immunology"
DOI: 10.1089/vim.2018.0084
Abstract: Activated CD8+ lymphocytes infiltrate the brain in response to many viral infections; where some remain stationed long term as memory T cells. Brain-resident memory T cells (bTRM) are positioned to impart immediate defense against recurrent… read more here.
Keywords: cells following; brain resident; resident cells; following viral ... See more keywords
Skin-Resident γδ T Cells Exhibit Site-Specific Morphology and Activation States
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Immunology Research"
DOI: 10.1155/2019/9020234
Abstract: Skin-resident γδ T cells play an important role in maintaining the immune barrier at the epithelial surface. Their roles in wound healing, regulation of immune response to injury, and reepithelialization have been characterized extensively in… read more here.
Keywords: resident cells; skin resident; cell; morphology activation ... See more keywords
IFN-γ production by brain-resident cells activates cerebral mRNA expression of a wide spectrum of molecules critical for both innate and T cell-mediated protective immunity to control reactivation of chronic infection with Toxoplasma gondii
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2023.1110508
Abstract: We previously demonstrated that brain-resident cells produce IFN-γ in response to reactivation of cerebral infection with Toxoplasma gondii. To obtain an overall landscape view of the effects of IFN-γ from brain-resident cells on the cerebral… read more here.
Keywords: ifn production; resident cells; immunity; brain resident ... See more keywords
Liver-Derived TGF-β Maintains the EomeshiTbetlo Phenotype of Liver Resident Natural Killer Cells
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2019.01502
Abstract: The adult human liver hosts a complex repertoire of liver resident and transient natural killer (NK) cell populations with diverse phenotypes and functions. Liver resident NK cells are CD56bright NK cells defined by a unique… read more here.
Keywords: resident cells; phenotype liver; liver resident; liver ... See more keywords
Comparing Mouse and Human Tissue-Resident γδ T Cells
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.891687
Abstract: Circulating immune cell compartments have been extensively studied for decades, but limited access to peripheral tissue and cell yield have hampered our understanding of tissue-based immunity, especially in γδ T cells. γδ T cells are… read more here.
Keywords: mice humans; tissue resident; mouse; resident cells ... See more keywords
Toll-Like Receptors 1/2/4/6 and Nucleotide-Binding Oligomerization Domain-Like Receptor 2 Are Key Damage-Associated Molecular Patterns Sensors on Periodontal Resident Cells
Sign Up to like & getrecommendations! Published in 2021 at "Applied Sciences"
DOI: 10.3390/app11114724
Abstract: Background: Toll-like receptors (TLRs) and nucleotide-binding oligomerization domain (NOD)-like receptors (NLRs) are innate, damage-associated molecular patterns (DAMP) sensors. Their expressions in human periodontal resident cells and reactions toward irritations, such as hypoxia and lipopolysaccharide (LPS),… read more here.
Keywords: associated molecular; damage associated; resident cells; like receptors ... See more keywords