Isolation and Purification of Tissue Resident Macrophages for the Analysis of Nuclear Receptor Activity.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9130-3_5
Abstract: Tissue resident macrophages (TRMs) are multifunctional immune cells present in all tissues, contributing to the correct development, homeostasis, and protection against pathogens and injury. TRMs are morphologically and functionally heterogeneous, as a result of both… read more here.
Keywords: tissue resident; tissue; nuclear receptor; receptor activity ... See more keywords
Vagus nerve regulates the phagocytic and secretory activity of resident macrophages in the liver
Sign Up to like & getrecommendations! Published in 2019 at "Brain, Behavior, and Immunity"
DOI: 10.1016/j.bbi.2019.06.041
Abstract: The gastrointestinal (GI) tract harbors commensal microorganisms as well as invasive bacteria, toxins and other pathogens and, therefore, plays a pivotal barrier and immunological role against pathogenic agents. The vagus nerve is an important regulator… read more here.
Keywords: activity resident; macrophages liver; vagus nerve; nerve ... See more keywords
Bladder resident macrophages: Mucosal sentinels.
Sign Up to like & getrecommendations! Published in 2018 at "Cellular immunology"
DOI: 10.1016/j.cellimm.2018.01.018
Abstract: Macrophages are instrumental in the response to infectious and noninfectious diseases, however, their role in the bladder is poorly understood. Indeed, the bladder is a mucosal tissue frequently overlooked in research, despite the prevalence of… read more here.
Keywords: resident; macrophages mucosal; bladder resident; mucosal sentinels ... See more keywords
Generating tissue-resident macrophages from pluripotent stem cells: Lessons learned from microglia.
Sign Up to like & getrecommendations! Published in 2018 at "Cellular immunology"
DOI: 10.1016/j.cellimm.2018.01.019
Abstract: Over the past decades, the importance of the immune system in a broad scope of pathologies, has drawn attention towards tissue-resident macrophages, such as microglia in the brain. To enable the study of for instance… read more here.
Keywords: macrophages pluripotent; resident macrophages; stem cells; tissue resident ... See more keywords
Organ-Specific Fate, Recruitment, and Refilling Dynamics of Tissue-Resident Macrophages during Blood-Stage Malaria.
Sign Up to like & getrecommendations! Published in 2018 at "Cell reports"
DOI: 10.1016/j.celrep.2018.11.059
Abstract: Inflammation-induced disappearance of tissue-resident macrophages represents a key pathogen defense mechanism. Using a model of systemic blood-stage malaria, we studied the dynamics of tissue-resident macrophages in multiple organs to determine how they are depleted and… read more here.
Keywords: stage malaria; tissue resident; tissue; blood stage ... See more keywords
Tissue‐Resident Macrophages Are Locally Programmed for Silent Clearance of Apoptotic Cells
Sign Up to like & getrecommendations! Published in 2017 at "Immunity"
DOI: 10.1016/j.immuni.2017.10.006
Abstract: SUMMARY Although apoptotic cells (ACs) contain nucleic acids that can be recognized by Toll‐like receptors (TLRs), engulfment of ACs does not initiate inflammation in healthy organisms. Here we identified macrophage populations that continually engulf ACs… read more here.
Keywords: silent clearance; nucleic acids; apoptotic cells; expression ... See more keywords
Recruited macrophages that colonize the post-inflammatory peritoneal niche convert into functionally divergent resident cells
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-21778-0
Abstract: Inflammation generally leads to recruitment of monocyte-derived macrophages. What regulates the fate of these cells and to what extent they can assume the identity and function of resident macrophages is unclear. Here, we show that… read more here.
Keywords: macrophages colonize; inflammation; recruited macrophages; functionally divergent ... See more keywords
Hyaluronan-coated Prussian blue nanoparticles relieve LPS-induced peritonitis by suppressing oxidative species generation in tissue-resident macrophages.
Sign Up to like & getrecommendations! Published in 2022 at "Biomaterials science"
DOI: 10.1039/d1bm01796a
Abstract: Excessive inflammatory response during sepsis causes irreversible damage to healthy tissues and results in multi-organ failure. During infection, bacterial endotoxin-triggered inflammatory responses in macrophages facilitate the recruitment of circulating leukocytes, including neutrophils and monocytes. A… read more here.
Keywords: lps induced; tissue resident; prussian blue; resident macrophages ... See more keywords
Metabolic reprogramming of skeletal muscle by resident macrophages points to CSF1R inhibitors as muscular dystrophy therapeutics
Sign Up to like & getrecommendations! Published in 2022 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.abg7504
Abstract: The role of tissue-resident macrophages during tissue regeneration or fibrosis is not well understood, mainly due to the lack of a specific marker for their identification. Here, we identified three populations of skeletal muscle–resident myelomonocytic… read more here.
Keywords: muscular dystrophy; skeletal muscle; resident macrophages; muscle ... See more keywords
A Salivary Gland Resident Macrophage Subset Regulating Radiation Responses
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Dental Research"
DOI: 10.1177/00220345221150005
Abstract: Radiotherapy of head and neck cancers frequently leads to irreversible hypofunction of salivary glands, which severely compromises the quality of life and is extremely difficult to treat. We found recently that salivary gland resident macrophages… read more here.
Keywords: resident macrophages; resident; radiation; gland resident ... See more keywords
Tissue-resident macrophages promote early dissemination of multiple myeloma via IL-6 and TNFα.
Sign Up to like & getrecommendations! Published in 2021 at "Blood advances"
DOI: 10.1182/bloodadvances.2021005327
Abstract: Multiple myeloma (MM) is a plasma cell malignancy characterized by the presence of multiple foci in the skeleton. These distinct tumor foci represent cycles of tumor growth and dissemination that seed new clusters and drive… read more here.
Keywords: myeloma; tissue resident; early dissemination; multiple myeloma ... See more keywords