Association Between Measurable Residual Disease in Patients With Intermediate-Risk Acute Myeloid Leukemia and First Remission, Treatment, and Outcomes
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DOI: 10.1001/jamanetworkopen.2021.15991
Abstract: Key Points Question Is there an association between dynamic measurable residual disease, treatment, and outcomes among adults with intermediate-risk acute myeloid leukemia? Findings In this registry-based cohort study that included 549 younger patients (aged 14-60… read more here.
Keywords: risk acute; myeloid leukemia; measurable residual; residual disease ... See more keywords
Significance of recurrence of minimal residual disease detected by multi‐parameter flow cytometry in patients with acute lymphoblastic leukemia in morphological remission
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DOI: 10.1002/ajh.24629
Abstract: We sought to determine the significance of minimal residual disease (MRD) relapse in patients with ALL after achieving MRD negative status following induction and consolidation therapy. Between January 2003 and September 2014, 647 newly diagnosed… read more here.
Keywords: multi parameter; minimal residual; recurrence; remission ... See more keywords
Imaging and bone marrow assessments improve minimal residual disease prediction in multiple myeloma
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DOI: 10.1002/ajh.25507
Abstract: The value of minimal residual disease (MRD) status by bone marrow and imaging analysis as independent prognostic factors has been well established in multiple myeloma (MM). Nevertheless data about their potential complementarity for a more… read more here.
Keywords: pet; mrd pet; minimal residual; residual disease ... See more keywords
The early achievement of measurable residual disease negativity in the treatment of adults with Philadelphia‐negative B‐cell acute lymphoblastic leukemia is a strong predictor for survival
Sign Up to like & getrecommendations! Published in 2019 at "American Journal of Hematology"
DOI: 10.1002/ajh.25671
Abstract: The minimal or measurable residual disease (MRD) status following induction/consolidation chemotherapy is an important prognostic endpoint in adult patients with newly diagnosed acute lymphoblastic leukemia (ALL). However, the optimal time‐point (TP) of MRD assessment and… read more here.
Keywords: mrd; philadelphia negative; lymphoblastic leukemia; measurable residual ... See more keywords
SARS‐CoV‐2 vaccination induces breakthrough hemolysis in paroxysmal nocturnal hemoglobinuria on complement inhibitor
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DOI: 10.1002/ajh.26262
Abstract: 1. Avet-Loiseau H, San-Miguel J, Casneuf T, et al. Evaluation of sustained minimal residual disease negativity with daratumumabcombination regimens in relapsed and/or refractory multiple myeloma: analysis of POLLUX and CASTOR. J Clin Oncol. 2021;39(10): 1139-1149.… read more here.
Keywords: minimal residual; myeloma; multiple myeloma; residual disease ... See more keywords
Blinatumomab is associated with favorable outcomes in patients with B‐cell lineage acute lymphoblastic leukemia and positive measurable residual disease at a threshold of 10−4 and higher
Sign Up to like & getrecommendations! Published in 2022 at "American Journal of Hematology"
DOI: 10.1002/ajh.26634
Abstract: The presence of measurable residual disease (MRD) is the strongest predictor of relapse in acute lymphoblastic leukemia (ALL). We conducted a prospective, single‐arm, phase II study in adults with B‐cell ALL with MRD ≥1 × 10−4 after… read more here.
Keywords: residual disease; measurable residual; lymphoblastic leukemia; acute lymphoblastic ... See more keywords
Measurable residual disease monitoring in AML: Prospects for therapeutic decision‐making and new drug development
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DOI: 10.1002/ajh.27482
Abstract: Measurable residual disease (MRD) is strongly associated with risk of relapse and long‐term survival outcomes in patients with acute myeloid leukemia (AML). Apart from its clear prognostic impact, MRD information is also increasingly used to… read more here.
Keywords: measurable residual; decision making; residual disease; therapeutic decision ... See more keywords
Evaluating Minimal Residual Disease Negativity as a Surrogate Endpoint for Treatment Efficacy in Multiple Myeloma: A Meta‐Analysis of Randomized Controlled Trials
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DOI: 10.1002/ajh.27582
Abstract: This meta‐analysis examined the association between minimal residual disease (MRD) negativity and survival outcomes in 15 304 patients with multiple myeloma (MM) enrolled in randomized controlled trials published until June 2, 2024. Overall, there was a… read more here.
Keywords: residual disease; minimal residual; meta analysis; negativity ... See more keywords
Impact of residual disease biomarkers on the prognosis of HER2-positive breast cancer following neoadjuvant therapy.
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DOI: 10.1002/cam4.5839
Abstract: The changes in prognostic factors and clinicopathological characteristics of residual disease following neoadjuvant therapy (NAT) for breast cancer are important references for postoperative adjuvant therapy. The analyses of the relationship between the clinicopathological characteristics of… read more here.
Keywords: residual disease; breast cancer; cancer; following neoadjuvant ... See more keywords
Clinical impact of minimal residual disease and genetic subtypes on the prognosis of childhood acute lymphoblastic leukemia
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DOI: 10.1002/cncr.34606
Abstract: This study analyzed data from two consecutive protocols for children newly diagnosed with acute lymphoblastic leukemia (ALL) to determine the clinical impact of minimal/measurable residual disease (MRD) and recently identified tumor genetic subtypes. read more here.
Keywords: residual disease; genetic subtypes; impact minimal; lymphoblastic leukemia ... See more keywords
Peritransplant lysine methyltransferase 2a–rearranged measurable residual disease dynamics as a prognostic marker in adult acute myeloid leukemia
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DOI: 10.1002/cncr.70044
Abstract: This study examined the impact of measurable residual disease (MRD) dynamics in adults with lysine methyltransferase 2a rearrangement (KMT2Ar) in acute myeloid leukemia (AML) during the peritransplant period (before and early after allogeneic hematopoietic stem… read more here.
Keywords: measurable residual; lysine methyltransferase; acute myeloid; residual disease ... See more keywords