Influence of Residual Solvents on the Physical Properties of Transdermal Drug Delivery Systems.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2020.119713
Abstract: The purpose of this investigation was to systematically assess the effect of residual solvents on the physical properties of a silicone adhesive-based transdermal system (TDS) containing n-heptane and o-xylene as residual solvents. The processing temperature… read more here.
Keywords: contents residual; residual solvents; solvents physical; physical properties ... See more keywords
SPME fiber coated by arrayed ZNRs for sampling and concentration of polar residual solvents for further analysis using GC FID.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of pharmaceutical and biomedical analysis"
DOI: 10.1016/j.jpba.2019.06.037
Abstract: In this work, fused silica coated by arrayed ZNRs were successfully applied as a sorbent for analysis of polar residual solvents in pantoprazole feedstocks. ZnO nanoparticles were produced and deposited on a fused silica surface… read more here.
Keywords: arrayed znrs; residual solvents; analysis; fiber ... See more keywords
A generic gas chromatography method for determination of residual solvents in PET radiopharmaceuticals.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of pharmaceutical and biomedical analysis"
DOI: 10.1016/j.jpba.2021.114425
Abstract: A novel gas chromatography (GC) method for quantitation of volatile organic compounds (VOCs) in 18F- and 11C-radiopharmaceuticals listed in the European Pharmacopoeia (Ph. Eur.) was proposed. Optimized chromatographic parameters were used for separation of ethanol,… read more here.
Keywords: gas chromatography; pet radiopharmaceuticals; residual solvents; method ... See more keywords
Optimized synthesis of suvorexant and determination of eight residual solvents by headspace gas chromatography
Sign Up to like & getrecommendations! Published in 2025 at "RSC Advances"
DOI: 10.1039/d5ra06779k
Abstract: This study presents an optimized synthetic pathway for suvorexant and establishes a robust method for the simultaneous determination of residual solvents. The synthesis commenced with chiral precursors, specifically (R)-3-(BOC-amino)butyric acid and N-benzyl glycine ethyl ester,… read more here.
Keywords: residual solvents; gas chromatography; optimized synthesis; eight residual ... See more keywords