Anti-HK antibody reveals critical roles of a 20-residue HK region for Aβ-induced plasma contact system activation
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DOI: 10.1182/bloodadvances.2021006612
Abstract: Key Points A 20-residue region in domain 6 of HK plays a critical role in Aβ42-induced contact system activation. 3E8 blocks PK and FXI binding to HK, disassembles HK/PK and HK/FXI complexes, and delays intrinsic… read more here.
Keywords: residue region; system activation; contact system;