Lysine Deacetylase Substrate Selectivity: Distinct Interaction Surfaces Drive Positive and Negative Selection for Residues Following Acetyllysine
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DOI: 10.1021/acs.biochem.3c00001
Abstract: Lysine acetylation is a post-translational modification that is reversed by lysine deacetylases (KDACs). The goal of this work was to identify determinants of substrate specificity for KDACs, focusing on short-range interactions occurring with residues immediately… read more here.
Keywords: negative selection; interaction; following acetyllysine; substrate ... See more keywords