The "Janus face" of the thrombin binding aptamer: Investigating the anticoagulant and antiproliferative properties through straightforward chemical modifications.
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DOI: 10.1016/j.bioorg.2017.11.005
Abstract: BACKGROUND The thrombin binding aptamer (TBA) is endowed with both anticoagulant and antiproliferative activities. Its chemico-physical and/or biological properties can be tuned by the site-specific replacement of selected residues. METHODS Four oligodeoxynucleotides (ODNs) based on… read more here.
Keywords: binding aptamer; anticoagulant antiproliferative; antiproliferative properties; residues positions ... See more keywords