A patch of positively charged residues regulates the efficacy of clinical DR5 antibodies in solid tumors.
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DOI: 10.1016/j.celrep.2021.109953
Abstract: Receptor clustering is the first and critical step to activate apoptosis by death receptor-5 (DR5). The recent discovery of the autoinhibitory DR5 ectodomain has challenged the long-standing view of its mechanistic activation by the natural… read more here.
Keywords: residues regulates; dr5 antibodies; positively charged; charged residues ... See more keywords