Effects of early intravesical administration of resiniferatoxin to spinal cord‐injured rats in neurogenic detrusor overactivity
Sign Up to like & getrecommendations! Published in 2019 at "Neurourology and Urodynamics"
DOI: 10.1002/nau.24032
Abstract: To investigate if intravesical administration during spinal shock of resiniferatoxin (RTX), an ultrapotent desensitizing agonist of transient receptor potential vanilloid‐1 (TRPV1), would silence TRPV1‐expressing bladder afferents at an early stage of disease progression and modulate… read more here.
Keywords: neurogenic detrusor; intravesical administration; detrusor overactivity; resiniferatoxin ... See more keywords
Total Synthesis of Resiniferatoxin Enabled by Photocatalytic Decarboxylative Radical Cyclization.
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DOI: 10.1021/acs.orglett.1c04286
Abstract: Resiniferatoxin (1) is a complex daphnane diterpenoid with a highly oxygenated 5/7/6-membered ABC-ring system. Here we report a new synthetic route to 1 that requires 27 steps from a starting d-ribose derivative. The carbon spacer… read more here.
Keywords: resiniferatoxin; synthesis resiniferatoxin; resiniferatoxin enabled; decarboxylative radical ... See more keywords
Imaging the influence of peripheral TRPV1-signaling on cerebral nociceptive processing applying fMRI-based graph theory in a resiniferatoxin rat model
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DOI: 10.1371/journal.pone.0266669
Abstract: Resiniferatoxin (RTX), an extract from the spurge plant Euphorbia resinifera, is a potent agonist of the transient receptor potential cation channel subfamily V member 1 (TRPV1), mainly expressed on peripheral nociceptors—a prerequisite for nociceptive heat… read more here.
Keywords: resiniferatoxin; trpv1 signaling; rtx; influence ... See more keywords