Total Synthesis of Resiniferatoxin Enabled by Photocatalytic Decarboxylative Radical Cyclization.
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DOI: 10.1021/acs.orglett.1c04286
Abstract: Resiniferatoxin (1) is a complex daphnane diterpenoid with a highly oxygenated 5/7/6-membered ABC-ring system. Here we report a new synthetic route to 1 that requires 27 steps from a starting d-ribose derivative. The carbon spacer… read more here.
Keywords: resiniferatoxin; synthesis resiniferatoxin; resiniferatoxin enabled; decarboxylative radical ... See more keywords