Loss of Mediator complex subunit 13 (MED13) promotes resistance to alkylation through cyclin D1 upregulation
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DOI: 10.1093/nar/gkaa1289
Abstract: Abstract Alkylating drugs are among the most often used chemotherapeutics. While cancer cells frequently develop resistance to alkylation treatments, detailed understanding of mechanisms that lead to the resistance is limited. Here, by using genome-wide CRISPR–Cas9… read more here.
Keywords: med13; cyclin; resistance; mediator complex ... See more keywords