Structure and function of resistance arteries from BB-creatine kinase and ubiquitous Mt-creatine kinase double knockout mice
Sign Up to like & getrecommendations! Published in 2020 at "Amino Acids"
DOI: 10.1007/s00726-020-02872-x
Abstract: Increasing evidence indicates that the enzyme creatine kinase (CK) is intimately involved in microvascular contractility. The mitochondrial isoenzyme catalyses phosphocreatine synthesis from ATP, while cytoplasmic CK, predominantly the BB isoenzyme in vascular tissue, is tightly… read more here.
Keywords: resistance arteries; function; kinase; creatine kinase ... See more keywords
Cannabidiol selectively inhibits the contraction of rat small resistance arteries: possible role for CGRP and voltage-gated calcium channels.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2020.173767
Abstract: The pharmacology of cannabidiol, the non-psychoactive major component of Cannabis sativa, is of growing interest as it becomes more widely prescribed. This study aimed to examine the effects of cannabidiol on a wide range of… read more here.
Keywords: resistance arteries; calcium channels; small resistance; pharmacology ... See more keywords
Chronic iron overload induces functional and structural vascular changes in small resistance arteries via NADPH oxidase-dependent O2- production.
Sign Up to like & getrecommendations! Published in 2017 at "Toxicology letters"
DOI: 10.1016/j.toxlet.2017.07.497
Abstract: Iron overload leads to excessive free radical formation and induces cardiovascular dysfunction. Thus, our aim was to investigate the structural and endothelial modulation of vascular tone induced by chronic iron overload in mesenteric arteries. Rats… read more here.
Keywords: iron; chronic iron; resistance arteries; iron overload ... See more keywords
Sphingosine 1-phosphate-induced nitric oxide production simultaneously controls endothelial barrier function and vascular tone in resistance arteries.
Sign Up to like & getrecommendations! Published in 2021 at "Vascular pharmacology"
DOI: 10.1016/j.vph.2021.106874
Abstract: The regulations of endothelial permeability and vascular tone by the sphingosine 1-phosphate (S1P) have been well-studied independently. Little is known about whether effects of S1P on endothelial permeability can directly influence vascular tone in resistance… read more here.
Keywords: barrier; resistance arteries; tone; vascular tone ... See more keywords
Increased role of E prostanoid receptor-3 in prostacyclin-evoked contractile activity of spontaneously hypertensive rat mesenteric resistance arteries
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-09288-w
Abstract: This study aimed to determine whether E prostanoid receptor-3 (EP3) is involved in prostacyclin (PGI2)-evoked vasoconstrictor activity of resistance arteries and if so, how it changes under hypertensive conditions. Mesenteric resistance arteries from Wistar-Kyoto rats… read more here.
Keywords: mesenteric resistance; prostanoid receptor; activity; resistance arteries ... See more keywords
A key role for tetrahydrobiopterin‐dependent endothelial NOS regulation in resistance arteries: studies in endothelial cell tetrahydrobiopterin‐deficient mice
Sign Up to like & getrecommendations! Published in 2017 at "British Journal of Pharmacology"
DOI: 10.1111/bph.13728
Abstract: The cofactor tetrahydrobiopterin (BH4) is a critical regulator of endothelial NOS (eNOS) function, eNOS‐derived NO and ROS signalling in vascular physiology. To determine the physiological requirement for de novo endothelial cell BH4 synthesis for the… read more here.
Keywords: endothelial cell; tetrahydrobiopterin; resistance arteries; endothelial nos ... See more keywords
Vasoactive properties of hepatokines using mesenteric resistance arteries in male Wistar rats
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5730256
Abstract: Hepatokines, defined as proteins or protein-like substances secreted mainly or exclusively by the liver in an endocrine or paracrine way, play an essential role in modulating the metabolic progress and pathological conditions of the body.… read more here.
Keywords: resistance arteries; physiology; male wistar; vehicle ... See more keywords
Loss- and gain-of-function mutations in the Type 1 IP3 receptor (IP3R1) affect myogenic constriction of murine cerebral resistance arteries
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5731469
Abstract: Myogenic reactivity in resistance arteries/arterioles in response to changing intraluminal pressure is a key physiological mechanism for the regulation of blood pressure and flow. Although IP3-mediated intracellular Ca2+ release is known to contribute to the… read more here.
Keywords: function; mmhg; resistance arteries; pressure ... See more keywords
Endothelial Dysfunction and Phenylephrine-Induced Hypocontractility Occurs in Mesenteric Resistance Arteries Prior to the Onset of Alzheimer's Disease in Mice
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5731729
Abstract: Alzheimer’s Disease (AD) is the most common form of dementia and a major cause of disability and death among the older population. In addition, Cardiovascular dieseases (CVDs) and their risk factors are associated with an… read more here.
Keywords: phenylephrine induced; pathology; physiology; resistance arteries ... See more keywords
“A Step and a Ceiling”: mechanical properties of Ca2+ spark vasoregulation in resistance arteries by pressure‐induced oxidative activation of PKG
Sign Up to like & getrecommendations! Published in 2019 at "Physiological Reports"
DOI: 10.14814/phy2.14260
Abstract: We investigated the biomechanical relationship between intraluminal pressure within small mesenteric resistance arteries, oxidant activation of PKG, Ca2+ sparks, and BK channel vasoregulation. Mesenteric resistance arteries from wild type (WT) and genetically modified mice with… read more here.
Keywords: resistance arteries; activation pkg; resistance; vasoregulation ... See more keywords
Antioxidant Properties of Egg White Hydrolysate Prevent Mercury-Induced Vascular Damage in Resistance Arteries
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2020.595767
Abstract: Aim: We investigated the antioxidant protective power of egg white hydrolysate (EWH) against the vascular damage induced by mercury chloride (HgCl2) exposure in resistance arteries. Methods: Male Wistar rats received for 60 days: (I) intramuscular… read more here.
Keywords: white hydrolysate; egg white; resistance arteries; hgcl2 ... See more keywords