Prevalence of NS5A resistance associated substitutions in patients with hepatitis C virus genotypes 1a and 3: Impact on current therapeutic strategies
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Medical Virology"
DOI: 10.1002/jmv.25048
Abstract: The presence of resistance‐associated substitutions (RASs) at NS5A region might compromise the efficacy of Direct Acting Antiviral agents (DAAs). HCV resistance at NS5A region is mainly focused on patients with hepatitis C virus (HCV) genotypes… read more here.
Keywords: g1a; rass; prevalence; associated substitutions ... See more keywords
The presence of resistance‐associated mutations in reverse transcriptase gene is associated with cerebrospinal fluid HIV‐1 escape: A multicentric retrospective analysis
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Medical Virology"
DOI: 10.1002/jmv.28704
Abstract: Higher risk of cerebrospinal fluid escape (CVE) has been associated with the use of specific antiretroviral (ARV) classes, such as protease inhibitors. We assessed whether archived resistance‐associated mutations (RAMs) can mediate this relationship by identifying… read more here.
Keywords: associated mutations; reverse transcriptase; presence; cerebrospinal fluid ... See more keywords
Elevated Insulin and Insulin Resistance are Associated with Altered Myelin in Cognitively Unimpaired Middle‐Aged Adults
Sign Up to like & getrecommendations! Published in 2019 at "Obesity"
DOI: 10.1002/oby.22558
Abstract: Insulin regulates metabolism and influences neural health. Insulin resistance (IR) and type II diabetes have been identified as risk factors for Alzheimer disease (AD). Evidence has also suggested that myelinated white matter alterations may be… read more here.
Keywords: insulin; insulin insulin; resistance associated; insulin resistance ... See more keywords
Influenza B viruses from different genetic backgrounds are variably impaired by neuraminidase inhibitor resistance-associated substitutions.
Sign Up to like & getrecommendations! Published in 2019 at "Antiviral research"
DOI: 10.1016/j.antiviral.2019.104669
Abstract: Identifying evolutionary routes to antiviral resistance among influenza viruses informs molecular-based resistance surveillance and clinical decisions. To improve antiviral management and understand whether clinically identified neuraminidase (NA) inhibitor (NAI) resistance-associated markers affect influenza B viruses… read more here.
Keywords: influenza viruses; viruses different; neuraminidase inhibitor; resistance ... See more keywords
The resistance associated protein RIN4 promotes the extracellular transport of AtEXO70E2.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2021.03.072
Abstract: RIN4 is an important immunomodulator in Arabidopsis, which is targeted by multiple pathogenic effectors, and consequently guarded by different immune receptors. Although RIN4 plays a significant role in plant immunity, its molecular function is not… read more here.
Keywords: associated protein; rin4 promotes; transport; rin4 ... See more keywords
Defining Bedaquiline Susceptibility, Resistance, Cross-Resistance and Associated Genetic Determinants: A Retrospective Cohort Study
Sign Up to like & getrecommendations! Published in 2018 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2018.01.005
Abstract: Background Bedaquiline (BDQ) is a novel agent approved for use in combination treatment of multi-drug resistant tuberculosis (MDR-TB). We sought to determine BDQ epidemiological cut-off values (ECVs), define and assess interpretive criteria against putative resistance… read more here.
Keywords: cross resistance; resistance cross; bdq; resistance ... See more keywords
Prevalence of relevant NS5A resistance-associated substitutions to elbasvir in genotype 1a hepatitis C virus patients in Spain
Sign Up to like & getrecommendations! Published in 2018 at "Enfermedades Infecciosas Y Microbiologia Clinica"
DOI: 10.1016/j.eimce.2017.03.028
Abstract: Abstract Resistance-associated substitutions (RASs) to the new HCV NS5A inhibitor elbasvir may limit its efficacy and lead to virological failure in HCV-GT1a-infected patients. There are no data outside clinical trials evaluating their prevalence and impact… read more here.
Keywords: elbasvir; hcv; rass; prevalence ... See more keywords
Identification of drug resistance associated ncRNAs based on comprehensive heterogeneous network.
Sign Up to like & getrecommendations! Published in 2020 at "Life sciences"
DOI: 10.1016/j.lfs.2020.117256
Abstract: AIMS Chemotherapy and molecularly targeted therapy are main strategies for treatment of cancers. However, long-term treatment makes cancer cells acquire resistance to anti-cancer drugs, which severely limits the effects of cancer treatment. ncRNAs, especially miRNAs… read more here.
Keywords: drug resistance; network; drug; resistance ... See more keywords
HIV-1 gp41 genetic diversity and enfuvirtide resistance-associated mutations among enfuvirtide-naïve patients in southern China.
Sign Up to like & getrecommendations! Published in 2020 at "Virus research"
DOI: 10.1016/j.virusres.2020.198215
Abstract: BACKGROUND Human immunodeficiency virus (HIV) increasing molecular diversity and emergence of drug resistant mutants remain a major concern in China. Enfuvirtide (ENF/T-20) is the first entry inhibitor used in patients failing highly active antiretroviral therapy… read more here.
Keywords: diversity; southern china; resistance; resistance associated ... See more keywords
Discovery of MK-6169, a Potent Pan-Genotype Hepatitis C Virus NS5A Inhibitor with Optimized Activity against Common Resistance-Associated Substitutions.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.7b01927
Abstract: We describe the discovery of MK-6169, a potent and pan-genotype hepatitis C virus NS5A inhibitor with optimized activity against common resistance-associated substitutions. SAR studies around the combination of changes to both the valine and aminal… read more here.
Keywords: 6169 potent; associated substitutions; resistance associated; common resistance ... See more keywords
The structure of serum resistance-associated protein and its implications for human African trypanosomiasis
Sign Up to like & getrecommendations! Published in 2017 at "Nature Microbiology"
DOI: 10.1038/s41564-017-0085-3
Abstract: Only two trypanosome subspecies are able to cause human African trypanosomiasis. To establish an infection in human blood, they must overcome the innate immune system by resisting the toxic effects of trypanolytic factor 1 and… read more here.
Keywords: associated protein; human african; serum resistance; resistance associated ... See more keywords