Insulin resistance and breast cancer incidence and mortality in postmenopausal women in the Women’s Health Initiative
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DOI: 10.1002/cncr.33002
Abstract: Insulin resistance is associated with higher all‐cause and cancer‐specific mortality in postmenopausal women. However, to the authors' knowledge, information regarding insulin resistance and breast cancer mortality risk is limited. Therefore, the authors examined associations between… read more here.
Keywords: cancer; resistance breast; mortality; insulin resistance ... See more keywords
MCAM/CD146 promotes tamoxifen resistance in breast cancer cells through induction of epithelial-mesenchymal transition, decreased ERα expression and AKT activation.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer letters"
DOI: 10.1016/j.canlet.2016.11.004
Abstract: Tamoxifen resistance presents a prominent clinical challenge in endocrine therapy for hormone sensitive breast cancer. However, the underlying mechanisms that contribute to tamoxifen resistance are not fully understood. In this study, we established a tamoxifen… read more here.
Keywords: resistance breast; resistance; tamoxifen resistance; breast cancer ... See more keywords
LMTK3 confers chemo-resistance in breast cancer
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DOI: 10.1038/s41388-018-0197-0
Abstract: Lemur tyrosine kinase 3 (LMTK3) is an oncogenic kinase that is involved in different types of cancer (breast, lung, gastric, colorectal) and biological processes including proliferation, invasion, migration, chromatin remodeling as well as innate and… read more here.
Keywords: cancer; resistance breast; lmtk3; breast cancer ... See more keywords
Proline rich 11 (PRR11) overexpression amplifies PI3K signaling and promotes antiestrogen resistance in breast cancer
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DOI: 10.1038/s41467-020-19291-x
Abstract: The 17q23 amplicon is associated with poor outcome in ER+ breast cancers, but the causal genes to endocrine resistance in this amplicon are unclear. Here, we interrogate transcriptome data from primary breast tumors and find… read more here.
Keywords: pi3k; breast; prr11; resistance breast ... See more keywords
Isoliquiritin modulates ferroptosis via NF-κB signalling inhibition and alleviates doxorubicin resistance in breast cancer.
Sign Up to like & getrecommendations! Published in 2023 at "Immunopharmacology and immunotoxicology"
DOI: 10.1080/08923973.2023.2165943
Abstract: CONTEXT Breast cancer (BC) is the most prevalent diagnosed tumour and the major reason of tumour-related death in females around the world. Isoliquiritin, a type of plant extract, has exhibited the probable inhibitory effect in… read more here.
Keywords: isoliquiritin; breast cancer; breast; resistance breast ... See more keywords
ECM1 is associated with endocrine resistance in ER+ breast cancers
Sign Up to like & getrecommendations! Published in 2022 at "Animal Cells and Systems"
DOI: 10.1080/19768354.2022.2083235
Abstract: ABSTRACT Extracellular matrix protein 1 (ECM1) is associated with a poor prognosis of breast cancers. However, the role of ECM1 with endocrine resistance in estrogen receptor-positive (ER+) breast cancers has not been elucidated yet. We… read more here.
Keywords: breast; ecm1 associated; breast cancers; resistance breast ... See more keywords
tRNA-derived small RNA fragments (tRFs) as potential biomarkers for doxorubicin resistance in breast cancer.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2019.37.15_suppl.e12000
Abstract: e12000 Background: It has been confirmed that tRNA-derived small RNA fragments (tRFs) participate in various kinds of biological activities. However, the function of tRFs in chemotherapy resistance in breast cancer still remains unclear. The purpose… read more here.
Keywords: trf 2023; breast; breast cancer; resistance breast ... See more keywords
Editorial: The molecular mechanisms of metastasis and therapeutic resistance in breast cancer
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2023.1194858
Abstract: COPYRIGHT © 2023 Liang, Zhang, Tse, Lin and Kruyt. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is… read more here.
Keywords: molecular mechanisms; metastasis therapeutic; editorial molecular; mechanisms metastasis ... See more keywords
Long Noncoding RNAs Involved in the Endocrine Therapy Resistance of Breast Cancer
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DOI: 10.3390/cancers12061424
Abstract: Long noncoding RNAs (lncRNAs) are defined as RNAs longer than 200 nucleotides that do not encode proteins. Recent studies have demonstrated that numerous lncRNAs are expressed in humans and play key roles in the development… read more here.
Keywords: endocrine therapy; resistance breast; breast cancer; cancer ... See more keywords
VDAC1 is regulated by BRD4 and contributes to JQ1 resistance in breast cancer
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DOI: 10.3892/ol.2019.10534
Abstract: Voltage-dependent anion channels (VDACs) are situated in the outer membrane of the mitochondria and serve as gatekeepers that control metabolite and ion exchange between the cytosol and mitochondria. VDAC1 is one of the most studied… read more here.
Keywords: analysis; resistance breast; breast cancer; vdac1 ... See more keywords