MYC and therapy resistance in cancer: risks and opportunities
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13319
Abstract: The MYC transcription factor, encoded by the c‐MYC proto‐oncogene, is activated by growth‐promoting signals, and is a key regulator of biosynthetic and metabolic pathways driving cell growth and proliferation. These same processes are deregulated in… read more here.
Keywords: myc therapy; resistance cancer; therapy resistance; resistance ... See more keywords
Drug Delivery: Multidrug Resistance in Cancer Circumvented Using a Cytosolic Drug Reservoir (Adv. Sci. 2/2018)
Sign Up to like & getrecommendations! Published in 2018 at "Advanced Science"
DOI: 10.1002/advs.201870006
Abstract: The sustained release of drug at adequate and stable cytosolic drug concentrations is found to be a feasible scheme to circumvent the multidrug resistance effect and serves as a promising guideline for drug design to… read more here.
Keywords: cytosolic drug; drug; resistance; resistance cancer ... See more keywords
Acquired resistance to cancer immunotherapy
Sign Up to like & getrecommendations! Published in 2018 at "Seminars in Immunopathology"
DOI: 10.1007/s00281-018-0692-y
Abstract: In recent times, advances in cancer immunotherapy have yielded impressive, durable clinical responses in patients with varied subtypes of cancer. However, a significant proportion of patients who initially demonstrate encouraging tumor regression develop resistance and… read more here.
Keywords: acquired resistance; resistance; cancer immunotherapy; resistance cancer ... See more keywords
Overcoming treatment resistance in cancer: Current understanding and tactics.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer letters"
DOI: 10.1016/j.canlet.2016.04.018
Abstract: Chemotherapy is the standard treatment for many, if not all, metastatic cancers. While chemotherapy is often capable of inducing cell death in tumors leading to shrinkage of the tumor bulk, many patients suffer from recurrence… read more here.
Keywords: treatment; treatment resistance; overcoming treatment; resistance cancer ... See more keywords
Does the use of melatonin overcome drug resistance in cancer chemotherapy?
Sign Up to like & getrecommendations! Published in 2018 at "Life sciences"
DOI: 10.1016/j.lfs.2018.01.024
Abstract: Our knowledge regarding the implications of melatonin in the therapy of numerous medical conditions, including cancer is constantly expanding. Melatonin can variably affect cancer pathology via targeting several key aspects of any neoplastic condition, including… read more here.
Keywords: drug resistance; malignant cells; resistance; resistance cancer ... See more keywords
Simplified Derivatives of Tetrandrine as Potent and Specific P-gp Inhibitors to Reverse Multidrug Resistance in Cancer Chemotherapy.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c02061
Abstract: Targeted inhibition of a drug efflux transporter P-glycoprotein (P-gp) is an important strategy to reverse multidrug resistance in cancer chemotherapy. In this study, a rationally structural simplification to natural tetrandrine was performed based on molecular… read more here.
Keywords: resistance cancer; multidrug resistance; reverse multidrug; cancer chemotherapy ... See more keywords
Dysoxylactam A: A Macrocyclolipopeptide Reverses P-Glycoprotein-Mediated Multidrug Resistance in Cancer Cells.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.9b02259
Abstract: A 17-membered macrocyclolipopeptide, named dysoxylactam A (1) comprising an unprecedented branched C19 fatty acid and an l-valine, was isolated from the plants of Dysoxylum hongkongense. The challenging relative configuration of 1 was established by means… read more here.
Keywords: dysoxylactam macrocyclolipopeptide; resistance; cancer cells; multidrug resistance ... See more keywords
USP24 promotes drug resistance during cancer therapy
Sign Up to like & getrecommendations! Published in 2021 at "Cell Death and Differentiation"
DOI: 10.1038/s41418-021-00778-z
Abstract: Drug resistance has remained an important issue in the treatment and prevention of various diseases, including cancer. Herein, we found that USP24 not only repressed DNA-damage repair (DDR) activity by decreasing Rad51 expression to cause… read more here.
Keywords: cancer; drug resistance; cancer therapy; resistance cancer ... See more keywords
The paradigm of drug resistance in cancer: an epigenetic perspective
Sign Up to like & getrecommendations! Published in 2022 at "Bioscience Reports"
DOI: 10.1042/bsr20211812
Abstract: Abstract Innate and acquired resistance towards the conventional therapeutic regimen imposes a significant challenge for the successful management of cancer for decades. In patients with advanced carcinomas, acquisition of drug resistance often leads to tumor… read more here.
Keywords: resistance cancer; therapy resistance; resistance; cancer ... See more keywords
Single-cell analysis reveals fibroblast clusters linked to immunotherapy resistance in cancer.
Sign Up to like & getrecommendations! Published in 2020 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-19-1384
Abstract: A subset of Cancer-Associated Fibroblasts (FAP+/CAF-S1) mediates immunosuppression in breast cancers (BC), but its heterogeneity and its impact on immunotherapy response remain unknown. Here, we identify 8 CAF-S1 clusters by analyzing more than 19000 single… read more here.
Keywords: single cell; caf; immunotherapy resistance; resistance ... See more keywords
Hematologic malignancies magnify the effect of body mass index on insulin resistance in cancer survivors
Sign Up to like & getrecommendations! Published in 2022 at "Blood Advances"
DOI: 10.1182/bloodadvances.2021006241
Abstract: Key Points Cancer survivors have disproportionately greater insulin resistance with increasing BMI compared with controls without malignancies. Our findings indicate that interventions targeting obesity will be needed to prevent the sequelae of insulin resistance in… read more here.
Keywords: resistance cancer; insulin resistance; cancer survivors;