Nonlocal Effects of Antibiotic-Resistance-Causing Mutations Reveal an Alternative Region for Targeting on FtsW-Penicillin-Binding Protein 3 Complex of Haemophilus influenzae
Sign Up to like & getrecommendations! Published in 2023 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.3c00127
Abstract: Currently prescribed antibiotics target the catalytic sites of wild-type bacterial proteins; however, bacteria adopt mutations at this site, eventually leading to the emergence of resistance. Therefore, the identification of alternative drug binding sites is crucial,… read more here.
Keywords: binding protein; haemophilus influenzae; resistance causing; resistance ... See more keywords
Analysing the impact of size of NGS panel in defining first line therapeutic strategies in NSCLC.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2025.43.16_suppl.3070
Abstract: 3070 Background: NCCN recommends the analysis of 8 genes (EGFR, ALK, ROS1, BRAF, KRAS, MET, RET, ERBB2, and NTRK1/2/3) for NSCLC patients to identify efficacious target therapies. Concerned with the rising incidence of sub-optimal response… read more here.
Keywords: panel; size; causing mutations; line ... See more keywords