A probabilistic approach to assess antibiotic resistance development risks in environmental compartments and its application to an intensive aquaculture production scenario.
Sign Up to like & getrecommendations! Published in 2017 at "Environmental pollution"
DOI: 10.1016/j.envpol.2017.08.079
Abstract: Estimating antibiotic pollution and antibiotic resistance development risks in environmental compartments is important to design management strategies that advance our stewardship of antibiotics. In this study we propose a modelling approach to estimate the risk… read more here.
Keywords: production; environmental compartments; resistance; antibiotic resistance ... See more keywords
Assessing In Vitro Resistance Development in Enterovirus A71 in the Context of Combination Antiviral Treatment.
Sign Up to like & getrecommendations! Published in 2021 at "ACS infectious diseases"
DOI: 10.1021/acsinfecdis.0c00872
Abstract: There are currently no antivirals available to treat infection with enterovirus A71 (EV-A71) or any other enterovirus. The extensively studied capsid binders rapidly select for drug-resistant variants. We here explore whether the combination of two… read more here.
Keywords: enterovirus a71; combination; enterovirus; resistance ... See more keywords
Determining &bgr;-lactam exposure threshold to suppress resistance development in Gram-negative bacteria
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DOI: 10.1093/jac/dkx001
Abstract: Objectives β-Lactams are commonly used for nosocomial infections and resistance to these agents among Gram-negative bacteria is increasing rapidly. Optimized dosing is expected to reduce the likelihood of resistance development during antimicrobial therapy, but the… read more here.
Keywords: gram negative; negative bacteria; resistance; resistance development ... See more keywords
Mutagenesis and Resistance Development of Bacteria Challenged by Silver Nanoparticles
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DOI: 10.1128/aac.00628-22
Abstract: Because of their extremely broad spectrum and strong biocidal power, nanoparticles of metals, especially silver (AgNPs), have been widely applied as effective antimicrobial agents against bacteria, fungi, and so on. However, the mutagenic effects of… read more here.
Keywords: resistance development; resistance; development bacteria; antimicrobial agents ... See more keywords
The Lysin Exebacase Has a Low Propensity for Resistance Development in Staphylococcus aureus and Suppresses the Emergence of Resistance to Antistaphylococcal Antibiotics
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DOI: 10.1128/spectrum.05261-22
Abstract: To guide development of an investigational new antibacterial drug, microbiological data are required to understand the potential for development of resistance to the drug in the target organism(s). Exebacase is a lysin (peptidoglycan hydrolase) that… read more here.
Keywords: exebacase; resistance development; development; staphylococcus aureus ... See more keywords
YES1 as a Therapeutic Target for HER2-Positive Breast Cancer after Trastuzumab and Trastuzumab-Emtansine (T-DM1) Resistance Development
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms222312809
Abstract: Trastuzumab-emtansine (T-DM1) is a therapeutic agent molecularly targeting human epidermal growth factor receptor 2 (HER2)-positive metastatic breast cancer (MBC), and it is especially effective for MBC with resistance to trastuzumab. Although several reports have described… read more here.
Keywords: resistance development; trastuzumab; breast cancer; resistance ... See more keywords