Resistance to DNA repair inhibitors in cancer
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13224
Abstract: The DNA damage response (DDR) represents a complex network of proteins which detect and repair DNA damage, thereby maintaining the integrity of the genome and preventing the transmission of mutations and rearranged chromosomes to daughter… read more here.
Keywords: resistance; ddr; cancer; resistance dna ... See more keywords
Relative Nuclease Resistance of a DNA Aptamer Covalently Conjugated to a Target Protein
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23147778
Abstract: A major obstacle to the therapeutic application of an aptamer is its susceptibility to nuclease digestion. Here, we confirmed the acquisition of relative nuclease resistance of a DNA-type thrombin binding aptamer with a warhead (TBA3)… read more here.
Keywords: nuclease resistance; resistance; target protein; relative nuclease ... See more keywords