Resistance to Epigenetic-Targeted Therapy Engenders Tumor Cell Vulnerabilities Associated with Enhancer Remodeling.
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DOI: 10.1016/j.ccell.2018.11.005
Abstract: Drug resistance represents a major challenge to achieving durable responses to cancer therapeutics. Resistance mechanisms to epigenetically targeted drugs remain largely unexplored. We used bromodomain and extra-terminal domain (BET) inhibition in neuroblastoma as a prototype… read more here.
Keywords: targeted therapy; epigenetic targeted; resistance epigenetic; resistance ... See more keywords