SWI/SNF catalytic subunits’ switch drives resistance to EZH2 inhibitors in ARID1A-mutated cells
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DOI: 10.1038/s41467-018-06656-6
Abstract: Inactivation of the subunits of SWI/SNF complex such as ARID1A is synthetically lethal with inhibition of EZH2 activity. However, mechanisms of de novo resistance to EZH2 inhibitors in cancers with inactivating SWI/SNF mutations are unknown.… read more here.
Keywords: ezh2 inhibitors; ezh2; swi snf; resistance ezh2 ... See more keywords