Whole-exome sequencing identifies key mutated genes in T790M wildtype/cMET-unamplified lung adenocarcinoma with acquired resistance to first-generation EGFR tyrosine kinase inhibitors
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cancer Research and Clinical Oncology"
DOI: 10.1007/s00432-018-2634-4
Abstract: PurposeLung cancer is the leading cause of cancer-related death worldwide. Lung adenocarcinoma harboring EGFR-activating mutations will inevitably acquire resistance to first-generation EGFR tyrosine kinase inhibitors (TKIs). EGFR T790M mutation and cMET amplification are common mechanisms.… read more here.
Keywords: lung adenocarcinoma; first generation; generation egfr; resistance first ... See more keywords
Analysis of molecular resistance and associated risk factors in tuberculosis
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DOI: 10.1186/s12879-025-10615-0
Abstract: Local surveillance of molecular resistance to first-line anti-tuberculosis (TB) drugs and fluoroquinolones (FQs) was initiated in 2019, but existing reports remain limited, hindering effective TB prevention and control efforts. This study aims to investigate molecular… read more here.
Keywords: resistance; molecular resistance; first line; line anti ... See more keywords