Long non-coding RNA HNF1A-AS1 induces 5-FU resistance of gastric cancer through miR-30b-5p/EIF5A2 pathway
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DOI: 10.1016/j.tranon.2022.101351
Abstract: Highlights • HNF1A-AS1 promotes 5-FU resistance in gastric cancer cells.• HNF1A-AS1 regulates EIF5A2 expression through sponging miR-30b-5p.• HNF1A-AS1 promotes EMT process and 5-FU resistance through miR-30b-5p/EIF5A2 pathway.• HNF1A-AS1 promotes 5-FU resistance in gastric cancer in… read more here.
Keywords: gastric cancer; mir 30b; resistance gastric; hnf1a as1 ... See more keywords
Long noncoding RNA OVAAL enhances nucleotide synthesis through pyruvate carboxylase to promote 5‐fluorouracil resistance in gastric cancer
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DOI: 10.1111/cas.15453
Abstract: 5‐Fluorouracil (5‐FU) is widely used in gastric cancer treatment, yet 5‐FU resistance remains an important clinical challenge. We established a model based on five long noncoding RNAs (lncRNA) to effectively assess the prognosis of gastric… read more here.
Keywords: long noncoding; gastric cancer; pyruvate carboxylase; resistance gastric ... See more keywords
M6A demethylase fat mass and obesity‐associated protein regulates cisplatin resistance of gastric cancer by modulating autophagy activation through ULK1
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DOI: 10.1111/cas.15469
Abstract: Drug resistance is an important factor for treatment failure of gastric cancer. N6‐methyladenosine (m6A) is the predominant mRNA internal modification in eukaryotes. The roles of m6A modification in drug resistance of gastric cancer remains unclear.… read more here.
Keywords: cisplatin resistance; gastric cancer; m6a; resistance gastric ... See more keywords
NHE1 Mediates 5-Fu Resistance in Gastric Cancer via STAT3 Signaling Pathway
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DOI: 10.2147/ott.s256274
Abstract: Background Several recent studies have addressed the role of Na+/H+ exchanger isoform 1 (NHE1) in tumor cell growth and apoptosis, including in gastric cancer. However, the role of NHE1 expression related to the 5-Fu resistance… read more here.
Keywords: resistance gastric; stat3; resistance; gastric cancer ... See more keywords
The multiple combination of Paclitaxel, Ramucirumab and Elacridar reverses the paclitaxel-mediated resistance in gastric cancer cell lines
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DOI: 10.3389/fonc.2023.1129832
Abstract: Introduction Paclitaxel (PTX) interferes with microtubule architecture by binding to β-tubulin, thereby blocking progression at the G2/M phase and inducing apoptosis. This study aimed to investigate molecular processes underlying PTX-mediated resistance in gastric cancer (GC)… read more here.
Keywords: mediated resistance; ptx; ramucirumab; elacridar ... See more keywords