An in silico pharmacological approach toward the discovery of potent inhibitors to combat drug resistance HIV‐1 protease variants
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DOI: 10.1002/jcb.28181
Abstract: Protease inhibitors (PIs) are crucial drugs in highly active antiretroviral therapy for human immunodeficiency virus‐1 (HIV‐1) infections. However, resistance owing to mutations challenge the long‐term efficacy in the medication of HIV‐1‐infected individuals. Lopinavir (LPV) and… read more here.
Keywords: drug resistance; protease; hiv; resistance hiv ... See more keywords
Analysis of drug resistance in HIV protease
Sign Up to like & getrecommendations! Published in 2018 at "BMC Bioinformatics"
DOI: 10.1186/s12859-018-2331-y
Abstract: BackgroundDrug resistance in HIV is the major problem limiting effective antiviral therapy. Computational techniques for predicting drug resistance profiles from genomic data can accelerate the appropriate choice of therapy. These techniques can also be used… read more here.
Keywords: drug resistance; protease; resistance hiv; resistance ... See more keywords