Tumour-intrinsic resistance to immune checkpoint blockade
Sign Up to like & getrecommendations! Published in 2019 at "Nature Reviews Immunology"
DOI: 10.1038/s41577-019-0218-4
Abstract: ‘Immune checkpoint blockade’ for cancer describes the use of therapeutic antibodies that disrupt negative immune regulatory checkpoints and unleash pre-existing antitumour immune responses. Antibodies targeting the checkpoint molecules cytotoxic T lymphocyte antigen 4 (CTLA4), programmed… read more here.
Keywords: checkpoint blockade; immune checkpoint; resistance immune; checkpoint ... See more keywords
Resistance to Immune Checkpoint Blockade: IFNγ or MHC-I?
Sign Up to like & getrecommendations! Published in 2023 at "Cancer immunology research"
DOI: 10.1158/2326-6066.cir-23-0373
Abstract: Resistance to immune checkpoint blockade (ICB), a subject of increasing interest and relevance in the current cancer treatment landscape, is likely induced by several different and incompletely understood mechanisms, including host T-cell dysfunction/exhaustion, T-cell exclusion… read more here.
Keywords: checkpoint blockade; resistance immune; resistance; immune checkpoint ... See more keywords
Overcoming resistance to immune checkpoint inhibitors in hepatocellular carcinoma: Challenges and opportunities
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.958720
Abstract: Hepatocellular carcinoma is one of the leading causes of cancer mortality globally, and its incidence is increasing. Immune checkpoint therapy has revolutionized the treatment of hepatocellular carcinoma over the past few years. However, only a… read more here.
Keywords: hepatocellular carcinoma; resistance immune; checkpoint inhibitors; immune checkpoint ... See more keywords
Wnt/β-Catenin Signaling and Resistance to Immune Checkpoint Inhibitors: From Non-Small-Cell Lung Cancer to Other Cancers
Sign Up to like & getrecommendations! Published in 2023 at "Biomedicines"
DOI: 10.3390/biomedicines11010190
Abstract: Lung cancer is the leading cause of cancer-related deaths worldwide. The standard of care for advanced non-small-cell lung cancer (NSCLC) without driver-gene mutations is a combination of an anti-PD-1/PD-L1 antibody and chemotherapy, or an anti-PD-1/PD-L1… read more here.
Keywords: resistance immune; checkpoint inhibitors; immune checkpoint; resistance ... See more keywords
Combining STAT3-Targeting Agents with Immune Checkpoint Inhibitors in NSCLC
Sign Up to like & getrecommendations! Published in 2023 at "Cancers"
DOI: 10.3390/cancers15020386
Abstract: Simple Summary Signal transducer and activator of transcription 3 (STAT3) plays a critical role in the development and progression of non-small cell lung cancer (NSCLC) tumors. Several reports suggest that STAT3 is involved in immunosuppression… read more here.
Keywords: combining stat3; resistance immune; checkpoint inhibitors; immune checkpoint ... See more keywords
Strategies to Overcome Resistance to Immune-Based Therapies in Osteosarcoma
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24010799
Abstract: Improving the prognosis and cure rate of HGOSs (high-grade osteosarcomas) is an absolute need. Immune-based treatment approaches have been increasingly taken into consideration, in particular for metastatic, relapsed and refractory HGOS patients, to ameliorate the… read more here.
Keywords: resistance immune; based therapies; strategies overcome; overcome resistance ... See more keywords