Differential Response and Resistance to KRAS‐Targeted Therapy
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DOI: 10.1002/mc.23908
Abstract: KRAS is the most frequently mutated oncogene. In epithelial malignancies such as lung, colorectal, and pancreatic tumors, KRAS is mutated in 25 to above 90% cases. KRAS was considered undruggable for over three decades until… read more here.
Keywords: resistance; kras targeted; resistance kras; response ... See more keywords
Abstract 1938: WEE1 inhibition prevents and overcomes resistance to KRAS inhibitors in lung cancer by enhancing MCL1-mediated apoptosis
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/1538-7445.am2024-1938
Abstract: Background: While novel covalent inhibitors of KRAS G12C have been approved in non-small-cell lung cancer (NSCLC), their efficacies are known to be limited. To enhance the therapeutic potential of KRAS inhibitors, combination strategies need to… read more here.
Keywords: cancer; combination; lung cancer; kras inhibitors ... See more keywords
Abstract LB278: KEAP1 loss-of-function modulates ROS and AKT-mTOR pathway leading to resistance to KRAS inhibitor
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-lb278
Abstract: Resistance to KRAS G12C inhibitors remains a significant clinical challenge in the treatment of non-small cell lung cancer (NSCLC). Among KRAS-mutated NSCLC cases, which account for approximately 30% of all NSCLC, the G12C subtype is… read more here.
Keywords: resistance; resistance kras; keap1; kras g12c ... See more keywords
Resistance to KRAS inhibition in advanced non-small cell lung cancer
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DOI: 10.3389/fonc.2024.1357898
Abstract: Lung cancer remains the leading cause of cancer death globally. More than 50% of new cases are diagnosed in an advanced or metastatic stage, thus contributing to the poor survival of such patients. Mutations in… read more here.
Keywords: lung cancer; cancer; inhibition; resistance kras ... See more keywords
Fibroblasts Promote Resistance to KRAS Silencing in Colorectal Cancer Cells
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DOI: 10.3390/cancers16142595
Abstract: Simple Summary Novel therapies targeting KRAS offer treatment options for previously untreatable patients. However, in colorectal cancer (CRC), resistance to KRAS-targeted therapy develops rapidly, making it imperative to understand its underlying mechanisms. Cancer-associated fibroblasts (CAFs)… read more here.
Keywords: cancer; secreted factors; resistance kras; cell ... See more keywords
Glutathione peroxidase 2 overexpression promotes malignant progression and cisplatin resistance of KRAS-mutated lung cancer cells
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DOI: 10.3892/or.2022.8422
Abstract: Kirsten rat sarcoma viral oncogene homolog (KRAS) aberrations frequently occur in patients with lung cancer. Oncogenic KRAS is characterized by excessive reactive oxygen species (ROS) accumulation, thus, ROS detoxification may contribute to KRAS-driven lung tumorigenesis.… read more here.
Keywords: lung cancer; malignant progression; cisplatin resistance; resistance kras ... See more keywords