Inhibition of TXNRD or SOD1 overcomes NRF2-mediated resistance to β-lapachone
Sign Up to like & getrecommendations! Published in 2020 at "Redox Biology"
DOI: 10.1016/j.redox.2020.101440
Abstract: Alterations in the NRF2/KEAP1 pathway result in the constitutive activation of NRF2, leading to the aberrant induction of antioxidant and detoxification enzymes, including NQO1. The NQO1 bioactivatable agent β-lapachone can target cells with high NQO1… read more here.
Keywords: sod1; lapachone; inhibition; resistance lapachone ... See more keywords