Egr‐1 transcriptionally activates protein phosphatase PTP1B to facilitate hyperinsulinemia‐induced insulin resistance in the liver in type 2 diabetes
Sign Up to like & getrecommendations! Published in 2019 at "FEBS Letters"
DOI: 10.1002/1873-3468.13537
Abstract: During the development of type 2 diabetes mellitus (T2DM), hyperinsulinemia is the earliest symptom. It is believed that long‐term high insulin stimulation might facilitate insulin resistance in the liver, but the underlying mechanism remains unknown.… read more here.
Keywords: resistance liver; hyperinsulinemia; liver; type diabetes ... See more keywords
Isolinderalactone Resistance to the Liver Injury Induced by Oxaliplatin in Rats through Inhibiting IL-6/STAT3 Signal Pathway.
Sign Up to like & getrecommendations! Published in 2023 at "Anti-cancer agents in medicinal chemistry"
DOI: 10.2174/1871520623666230112165440
Abstract: BACKGROUND Oxaliplatin (OXA) is easy to cause sinusoidal obstruction syndrome (SOS), leading to liver injury. Isolinderalactone (ILL), one of the main components of Lindera aggregate, has been reported to have a preservative effect on the… read more here.
Keywords: signal pathway; liver injury; stat3 signal; resistance liver ... See more keywords
Exercise training-attenuated insulin resistance and liver injury in elderly pre-diabetic patients correlates with NLRP3 inflammasome
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1082050
Abstract: Background Diabetes is one of the most common metabolic diseases and continues to be a leading cause of death worldwide. The NLRP3 inflammasome has been shown to exert detrimental effects on diabetic models. However, evidence… read more here.
Keywords: pre diabetic; resistance liver; nlrp3 inflammasome; insulin resistance ... See more keywords
Inhibition of JNK/c-Jun-ATF2 Overcomes Cisplatin Resistance in Liver Cancer through down-Regulating Galectin-1
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DOI: 10.7150/ijbs.79163
Abstract: Due to drug resistance, the clinical response to cisplatin (CDDP) from patients with liver cancer is unsatisfactory. The alleviation or overcoming of CDDP resistance is an urgent problem to be solved in clinics. Tumor cells… read more here.
Keywords: resistance liver; liver cancer; resistance; jnk ... See more keywords