Novel approach to temozolomide resistance in malignant glioma: connexin43‐directed therapeutics
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DOI: 10.1016/j.coph.2018.05.002
Abstract: HighlightsCx43 regulates invasiveness, proliferation, and resistance of malignant glioma.Cx43 provides a permissive niche for the invasion and channel‐mediated TMZ resistance.Targeting Cx43 with C‐terminal peptidomimetics can sensitize glioblastoma to TMZ.Mechanism of action for peptidomimetics may be… read more here.
Keywords: malignant glioma; resistance malignant; resistance; cx43 ... See more keywords
Systems biology analysis of mitogen activated protein kinase inhibitor resistance in malignant melanoma
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DOI: 10.1186/s12918-018-0554-1
Abstract: BackgroundKinase inhibition in the mitogen activated protein kinase (MAPK) pathway is a standard therapy for cancer patients with activating BRAF mutations. However, the anti-tumorigenic effect and clinical benefit are only transient, and tumors are prone… read more here.
Keywords: melanoma; resistance; biology; inhibitor resistance ... See more keywords