Loss of H3K27 trimethylation promotes radiotherapy resistance in medulloblastoma and induces an actionable vulnerability to BET inhibition.
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DOI: 10.1158/0008-5472.can-21-0871
Abstract: Medulloblastoma has been categorized into four subgroups based on genetic, epigenetic, and transcriptional profiling. Radiation is used for treating medulloblastoma regardless of the subgroup. A better understanding of the molecular pathways determining radiotherapy response could… read more here.
Keywords: medulloblastoma; resistance; resistance medulloblastoma; radiotherapy resistance ... See more keywords