Abstract 491: Tankyrase-selective inhibitor STP1002 reverses resistance to MEK inhibitors in colorectal cancer with KRAS mutations
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-491
Abstract: Mitogen-activated protein kinase (MEK) inhibitors have shown promising results in KRAS-mutated cancers with constitutive activation of the RAS/RAF/MEK pathway. However, the intrinsic and acquired resistance to MEK inhibitors is frequently observed in clinical trials. Wnt/β-catenin… read more here.
Keywords: inhibitor; mek; mek inhibitors; resistance mek ... See more keywords
Induction of immunoglobulin transcription factor 2 and resistance to MEK inhibitor in melanoma cells
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DOI: 10.18632/oncotarget.17866
Abstract: Primary or acquired resistance to MEK inhibitors has been a barrier to successful treatment with MEK inhibitors in many tumors. In this study, we analyzed genome-wide gene expression profiling data from 6 sensitive and 6… read more here.
Keywords: resistance mek; transcription factor; resistance; mek ... See more keywords
Antigen Peptide Transporter 1 (TAP1) Promotes Resistance to MEK Inhibitors in Pancreatic Cancers
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DOI: 10.3390/ijms23137168
Abstract: Mitogen-activated protein kinase (MAPK) kinase (MEK) inhibitors show limited benefit in Kirsten rat sarcoma (KRAS) mutant pancreatic cancer due to drug resistance. To identify mechanisms of resistance to MEK inhibitor (MEKi), we employed a differential… read more here.
Keywords: meki resistant; mek inhibitors; resistance; resistance mek ... See more keywords