Phosphorylation of USP29 by CDK1 Governs TWIST1 Stability and Oncogenic Functions
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Science"
DOI: 10.1002/advs.202205873
Abstract: Triple‐negative breast cancer (TNBC) is a highly lethal malignancy with limited therapy options. TWIST1, a key transcriptional factor of epithelial‐mesenchymal transition (EMT), contributes to self‐renewal of cancer stem‐like cells (CSCs), chemo‐resistance, metastasis, and TNBC‐related death.… read more here.
Keywords: resistance metastasis; phosphorylation usp29; twist1; cdk1 ... See more keywords
DNA methyltransferase 1 inhibits microRNA-497 and elevates GPRC5A expression to promote chemotherapy resistance and metastasis in breast cancer
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Cell International"
DOI: 10.1186/s12935-022-02466-5
Abstract: Background Abnormal DNA methylation of tumor suppressor gene promoter has been found in breast cancer. Therefore, the current study set out to explore how DNA methyltransferase 1 (DNMT1) affects breast cancer through mediating miR-497/GPRC5A axis.… read more here.
Keywords: cancer; breast cancer; resistance metastasis; mir 497 ... See more keywords
Effect of Oxaliplatin-Loaded Poly (d,l-Lactide-co-Glycolic Acid) (PLGA) Nanoparticles Combined with Retinoic Acid and Cholesterol on Apoptosis, Drug Resistance, and Metastasis Factors of Colorectal Cancer
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DOI: 10.3390/pharmaceutics12020193
Abstract: Apoptosis signaling pathways, drug resistance, and metastasis are important targets to develop new cancer treatments. We developed cholesterol-coated Poly(d,l-Lactide-co-Glycolic Acid) (PLGA) nanoparticles for effective encapsulation and delivery of retinoic acid and oxaliplatin to analyze their… read more here.
Keywords: drug resistance; retinoic acid; resistance metastasis;
Molecular mechanisms targeting drug-resistance and metastasis in colorectal cancer: Updates and beyond
Sign Up to like & getrecommendations! Published in 2023 at "World Journal of Gastroenterology"
DOI: 10.3748/wjg.v29.i9.1395
Abstract: Colorectal cancer (CRC) is the third most diagnosed malignancy and a major leading cause of cancer-related deaths worldwide. Despite advances in therapeutic regimens, the number of patients presenting with metastatic CRC (mCRC) is increasing due… read more here.
Keywords: resistance metastasis; colorectal cancer; resistance; cancer ... See more keywords
TCF7L2 promotes anoikis resistance and metastasis of gastric cancer by transcriptionally activating PLAUR
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Biological Sciences"
DOI: 10.7150/ijbs.69933
Abstract: Gastric cancer (GC) is the most common gastrointestinal malignant tumor, and distant metastasis is a critical factor in the prognosis of patients with GC. Understanding the mechanism of GC metastasis will help improve patient prognosis.… read more here.
Keywords: metastasis; promotes anoikis; resistance metastasis; anoikis resistance ... See more keywords