Molecular follow-up of first-line treatment by osimertinib in lung cancer: Importance of using appropriate tools for detecting EGFR resistance mutation C797S.
Sign Up to like & getrecommendations! Published in 2021 at "Cancer genetics"
DOI: 10.1016/j.cancergen.2021.06.001
Abstract: The C797S mutation encoded by EGFR exon 20 is classically observed as a tertiary event in EGFR-mutant non-small-cell lung carcinoma (NSCLC) primarily treated by first generation tyrosine kinase inhibitors (TKI) and secondarily treated by third-generation… read more here.
Keywords: egfr; first line; resistance mutation; resistance ... See more keywords
Fungicide resistance frequencies of Botrytis cinerea greenhouse isolates and molecular detection of a novel SDHI resistance mutation.
Sign Up to like & getrecommendations! Published in 2022 at "Pesticide biochemistry and physiology"
DOI: 10.1016/j.pestbp.2022.105058
Abstract: Sensitivity of B. cinerea to commonly used fungicides against Gray mold with emphasis to the newer quinone outside inhibitor (QoIs), and succinate dehydrogenase inhibitors (SDHIs) was assessed during a monitoring survey from vegetable greenhouses in… read more here.
Keywords: resistance mutation; resistance; resistance frequencies; sdhi resistance ... See more keywords
HIV-1 drug resistance mutation analyses of Cameroon derived Integrase sequences.
Sign Up to like & getrecommendations! Published in 2020 at "AIDS research and human retroviruses"
DOI: 10.1089/aid.2020.0022
Abstract: HIV-1 Integrase (IN) is a primary target for combination antiretroviral therapy (cART). Only a limited number of studies report on the emergence of resistance-associated mutations (RAMs) in Cameroon. We observed that (1.4%) of sequence from… read more here.
Keywords: hiv drug; cameroon; resistance mutation; resistance ... See more keywords
A Novel Environmental Azole Resistance Mutation in Aspergillus fumigatus and a Possible Role of Sexual Reproduction in Its Emergence
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DOI: 10.1128/mbio.00791-17
Abstract: ABSTRACT This study investigated the dynamics of Aspergillus fumigatus azole-resistant phenotypes in two compost heaps with contrasting azole exposures: azole free and azole exposed. After heat shock, to which sexual but not asexual spores are… read more here.
Keywords: resistance mutation; compost; azole; resistance ... See more keywords