Development of HIV Drug‐Resistance Mutations and Antiretroviral Efficacy Among Vietnamese Patients After Failure of 5‐Year First‐Line Therapy
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.25157
Abstract: The emergence of drug‐resistant mutations in human immunodeficiency virus (HIV) over time presents a challenge to treatment. We describe the development of drug‐resistance mutations and ART efficacy reduction in Vietnamese patients with failure of first‐line… read more here.
Keywords: first line; drug; drug resistance; patients failure ... See more keywords
The prevalence of HIV resistance mutations and their influence on the shedding of HIV‐1 into peritoneal dialysis effluent
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Medical Virology"
DOI: 10.1002/jmv.29734
Abstract: HIV drug resistance mutations (HIVDRMs) are important determinants of therapeutic effects and outcomes even in end‐stage kidney failure (ESKF) people living with HIV (PLWHIV). This study evaluated the prevalence of HIVDRMs and their effect on… read more here.
Keywords: resistance; hiv; hiv peritoneal; shedding hiv ... See more keywords
Identification and geographical distribution of pyrethroid resistance mutations in the poultry red mite Dermanyssus gallinae.
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DOI: 10.1002/ps.5582
Abstract: BACKGROUND The poultry red mite (PRM) Dermanyssus gallinae is the most common ectoparasite on poultry and causes high economic losses in poultry farming worldwide. Pyrethroid acaricides have been widely used for its control and, consequently,… read more here.
Keywords: geographical distribution; resistance; resistance mutations; pyrethroid resistance ... See more keywords
A comprehensive assessment of insecticide resistance mutations in source and immigrant populations of the diamondback moth Plutella xylostella (L.).
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DOI: 10.1002/ps.7223
Abstract: BACKGROUND The diamondback moth (DBM) Plutella xylostella has developed resistance to almost all insecticides used to control it. Populations of DBM in temperate regions mainly migrate from annual breeding areas. However, the distribution pattern of… read more here.
Keywords: resistance mutations; insecticide resistance; plutella xylostella; resistance ... See more keywords
Characterization of HIV-1 subtypes and drug resistance mutations in Henan Province, China (2017–2019)
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DOI: 10.1007/s00705-020-04606-6
Abstract: Human immunodeficiency virus type 1 (HIV-1) infection remains a severe public health problem worldwide. In this study, we investigated the distribution of HIV-1 subtypes and the prevalence of drug resistance mutations (DRMs) among patients with… read more here.
Keywords: drug resistance; hiv subtypes; hiv; resistance mutations ... See more keywords
Preclinical Prediction of Resistance Mutations and Proposal of Sequential Treatment Strategies for ALK-positive Lung Cancer Using Next-generation ALK Inhibitors
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DOI: 10.1007/s11095-025-03916-1
Abstract: Anaplastic lymphoma kinase (ALK) gene rearrangements occur in approximately 5% of non-small cell lung cancers (NSCLCs). Although ALK tyrosine kinase inhibitors provide substantial clinical benefits, acquired resistance-conferring mutations frequently emerge, leading to disease progression. Preclinical… read more here.
Keywords: resistance; alk inhibitors; preclinical prediction; resistance mutations ... See more keywords
Evaluation of drug resistance mutations in patients with chronic hepatitis B
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DOI: 10.1007/s12223-018-0650-z
Abstract: Mutations occurring in viral polymerase gene of hepatitis B virus (HBV) due to the use of nucleos(t)id analogs reduce the activity of the drugs by causing antiviral resistance. In this study, it was aimed to… read more here.
Keywords: drug resistance; evaluation drug; drug; resistance ... See more keywords
Drug resistance mutations in HIV: new bioinformatics approaches and challenges.
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DOI: 10.1016/j.coviro.2021.09.009
Abstract: Drug resistance mutations appear in HIV under treatment pressure. Resistant variants can be transmitted to treatment-naive individuals, which can lead to rapid virological failure and can limit treatment options. Consequently, quantifying the prevalence, emergence and… read more here.
Keywords: drug resistance; mutations hiv; resistance; resistance mutations ... See more keywords
Widespread resistance mutations to sulfadoxine-pyrimethamine in malaria parasites imported to China from Central and Western Africa
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DOI: 10.1016/j.ijpddr.2019.11.002
Abstract: Background Imported cases of infectious disease provide invaluable information about epidemiological conditions abroad, and should guide treatment decisions at home and abroad. Here, we examined cases of malaria imported from Africa to China for mutations… read more here.
Keywords: western africa; sulfadoxine pyrimethamine; resistance; first time ... See more keywords
TRANSMITTED DRUG RESISTANCE MUTATIONS AND TRENDS OF HIV-1 SUBTYPES IN TREATMENT-NAÏVE PATIENTS: A SINGLE CENTER EXPERIENCE.
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DOI: 10.1016/j.jgar.2019.08.024
Abstract: BACKGROUND Transmitted drug resistances (TDRs) and HIV-1 diversity could affect treatment efficacy and clinical outcomes. Here we describe the circulating viral subtypes and estimate the prevalence of resistance among drug naïve patients attending Sapienza University… read more here.
Keywords: drug resistance; treatment; transmitted drug; drug ... See more keywords
Magnetic Bead Processing Enables Sensitive Ligation-Based Detection of HIV Drug Resistance Mutations.
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DOI: 10.1021/acs.analchem.1c05040
Abstract: HIV develops single nucleotide polymorphisms (SNPs), some of which lead to drug resistance mutations (DRMs) that prevent therapeutic viral suppression. Genomic sequencing enables healthcare professionals to select effective combination antiretroviral therapy (ART) to achieve and… read more here.
Keywords: ligation based; processing; ligation; resistance mutations ... See more keywords