Ultrasound-sensitive siRNA-loaded nanobubbles fabrication and antagonism in drug resistance for NSCLC
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DOI: 10.1080/10717544.2021.2021321
Abstract: Abstract Due to the lack of safe, effective, and gene-targeted delivery technology. In this study, we have prepared nanobubbles loaded PDLIM5 siRNA (PDLIM5siRNA-NBs) to investigate the transfection efficiency and their antagonism in drug resistance in… read more here.
Keywords: resistance nsclc; drug; drug resistance; sirna ... See more keywords
Addressing CPI resistance in NSCLC: targeting TAM receptors to modulate the tumor microenvironment and future prospects
Sign Up to like & getrecommendations! Published in 2022 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2022-004863
Abstract: Lung cancer remains a leading cause of cancer death worldwide, with non-small-cell lung cancer (NSCLC) accounting for the majority of cases. Immune checkpoint inhibitors (CPIs), including those targeting programmed cell death protein-1 and its ligand… read more here.
Keywords: tam receptors; resistance nsclc; resistance; cpi resistance ... See more keywords
Licochalcone A Promotes the Ubiquitination of c-Met to Abrogate Gefitinib Resistance
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DOI: 10.1155/2022/5687832
Abstract: Met proto-oncogene (MET) amplification and tyrosine-protein kinase Met (c-Met) overexpression confer gefitinib resistance in non-small cell lung cancer (NSCLC). The natural product Licochalcone A (Lico A) exhibits a broad range of inhibitory effects against various… read more here.
Keywords: resistance nsclc; licochalcone; resistance; gefitinib resistance ... See more keywords
Loss of KMT5C Promotes EGFR Inhibitor Resistance in NSCLC via LINC01510-Mediated Upregulation of MET.
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DOI: 10.1158/0008-5472.can-20-0821
Abstract: EGFR inhibitors (EGFRi) are standard-of-care treatments administered to patients with non-small cell lung cancer (NSCLC) that harbor EGFR alterations. However, development of resistance posttreatment remains a major challenge. Multiple mechanisms can promote survival of EGFRi-treated… read more here.
Keywords: loss kmt5c; loss; resistance nsclc; resistance ... See more keywords
Hedgehog Pathway Activation Might Mediate Pemetrexed Resistance in NSCLC Cells
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DOI: 10.21873/anticanres.14087
Abstract: Background/Aim: Resistance to chemotherapeutic agents is the main cause of reduced survival in non-small cell lung cancer (NSCLC) patients. The Hedgehog (HH) pathway has been shown to be crucial in cell development and survival. Activated… read more here.
Keywords: pemetrexed resistance; hedgehog pathway; resistance nsclc; nsclc cells ... See more keywords
The pseudogene DUXAP10 contributes to gefitinib resistance in NSCLC by repressing OAS2 expression
Sign Up to like & getrecommendations! Published in 2022 at "Acta Biochimica et Biophysica Sinica"
DOI: 10.3724/abbs.2022176
Abstract: Gefitinib, an epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI),is the currently recommended first-line therapy for advanced EGFR-mutant lung cancer, and understanding the mechanism of resistance is the key to formulating therapeutic strategies for EGFR-TKIs. In… read more here.
Keywords: pseudogene duxap10; resistance nsclc; expression; gefitinib resistance ... See more keywords