Modulation of Myb‐induced NF‐kB ‐STAT3 signaling and resulting cisplatin resistance in ovarian cancer by dietary factors
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.28715
Abstract: c‐Myb regulates tumorigenesis in multiple cancers. Here we show, for the first time, the mechanism of c‐Myb‐mediated proliferation, invasion, and drug resistance in ovarian cancer (OC), the most lethal gynecological cancer, and a comparative analyses… read more here.
Keywords: resistance ovarian; proliferation invasion; ovarian cancer; myb ... See more keywords
FOXO3a Reverses the Cisplatin Resistance in Ovarian Cancer.
Sign Up to like & getrecommendations! Published in 2018 at "Archives of medical research"
DOI: 10.1016/j.arcmed.2018.04.014
Abstract: OBJECTIVE Ovarian cancer is one of the most serious disease in female reproductive system. Platinum is the first-line drug for the treatment of ovarian cancer, while the resistance of platinum drug in clinical hindered the… read more here.
Keywords: resistance ovarian; foxo3a; drug; ovarian cancer ... See more keywords
Tissue-based long non-coding RNAs "PVT1, TUG1 and MEG3" signature predicts Cisplatin resistance in ovarian Cancer.
Sign Up to like & getrecommendations! Published in 2020 at "Genomics"
DOI: 10.1016/j.ygeno.2020.08.005
Abstract: OBJECTIVES The current study aimed to investigate the potentiality of three lncRNAs "Plasmacytoma variant translocation 1(lnc-PVT1), Taurine upregulated gene type 1(lnc-TUG1) and Maternally expressed gene 3 (lnc-MEG-3)", to predict Cisplatin resistance in ovarian cancer (OC),… read more here.
Keywords: tug1; resistance ovarian; pvt1; lnc ... See more keywords
Biomarkers of drug resistance in ovarian cancer – an update
Sign Up to like & getrecommendations! Published in 2019 at "Expert Review of Molecular Diagnostics"
DOI: 10.1080/14737159.2019.1618187
Abstract: ABSTRACT Introduction: Ovarian cancer, consisting predominantly of ovarian carcinoma, is the most lethal gynecologic malignancy. Diagnosis at the advanced stage, particularly in high-grade serous carcinoma which is the most common and clinically aggressive histotype, is… read more here.
Keywords: drug resistance; resistance ovarian; ovarian cancer; cancer ... See more keywords
CircSETDB1 contributes to paclitaxel resistance of ovarian cancer cells by sponging miR-508-3p and regulating ABCC1 expression
Sign Up to like & getrecommendations! Published in 2022 at "Anti-Cancer Drugs"
DOI: 10.1097/cad.0000000000001465
Abstract: Ovarian cancer is a gynecological tumor with a poor prognosis. The chemotherapy failure and recurrence induced by paclitaxel (Ptx) resistance are the main reason for the failure of ovarian cancer treatment. In this study, we… read more here.
Keywords: resistance ovarian; ovarian cancer; mir 508; ptx resistance ... See more keywords
HSP90AB1 as the Druggable Target of Maggot Extract Reverses Cisplatin Resistance in Ovarian Cancer
Sign Up to like & getrecommendations! Published in 2023 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2023/9335440
Abstract: Cisplatin resistance is a crucial factor affecting ovarian cancer patient's survival rate, but the primary mechanism underlying cisplatin resistance in ovarian cancer remains unclear, and this prevents the optimal use of cisplatin therapy. Maggot extract… read more here.
Keywords: resistance ovarian; ovarian cancer; cisplatin resistance; medicine ... See more keywords
Abstract 4318: CD24 enhances cisplatin resistance in ovarian cancer by suppressing autophagy
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/1538-7445.am2024-4318
Abstract: Ovarian cancer is one of the most common gynecological cancers with the highest mortality rate. Most patients are diagnosed with advanced disease and will relapse due to chemoresistance. CD24, a highly glycosylated GPI-anchored membrane protein.… read more here.
Keywords: resistance ovarian; knockdown cd24; cancer; ovarian cancer ... See more keywords
Circular RNA circ_ARHGEF28 inhibits MST1/2 dimerization to suppress Hippo pathway to induce cisplatin resistance in ovarian cancer
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Cell International"
DOI: 10.1186/s12935-024-03451-w
Abstract: Cisplatin is integral to ovarian cancer treatment, yet resistance to this drug often results in adverse patient outcomes. The association of circular RNA (circRNA) with cisplatin resistance in ovarian cancer has been observed, but the… read more here.
Keywords: cisplatin resistance; cancer; circ arhgef28; ovarian cancer ... See more keywords
SIRT5-modified human umbilical cord mesenchymal stem cells loaded with antioxidant polydopamine nanozyme enhance parpi resistance in ovarian cancer via fatty acid metabolism reprogramming
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Nanobiotechnology"
DOI: 10.1186/s12951-025-03516-6
Abstract: Ovarian cancer remains one of the most aggressive cancers, and resistance to Poly (ADP-ribose) Polymerase inhibitors (PARPi) poses a major therapeutic challenge. SIRT5, a NAD + -dependent desuccinylase, plays a crucial role in regulating fatty acid metabolism,… read more here.
Keywords: cancer; resistance; parpi resistance; ovarian cancer ... See more keywords
CPEB4-Promoted Paclitaxel Resistance in Ovarian Cancer In Vitro Relies on Translational Regulation of CSAG2
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2020.600994
Abstract: Background: Drug resistance is a major obstacle in chemotherapy for ovarian cancer, wherein the up regulation of drug-resistant genes plays an important role. The cytoplasmic polyadenylation element binding protein 4 (CPEB4) is an RNA binding… read more here.
Keywords: cpeb4; resistance ovarian; paclitaxel resistance; ovarian cancer ... See more keywords