A minimal structural variation can overcome tumour resistance of oxaliplatin: the case of 4,5-dehydrogenation of the cyclohexane ring
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DOI: 10.1039/c9ra07760j
Abstract: A new family of anticancer compounds has been derived from oxaliplatin by inserting a double-bond between carbons 4 and 5 of the 1,2-diaminocyclohexane ring. read more here.
Keywords: minimal structural; tumour resistance; overcome tumour; variation overcome ... See more keywords
Enhanced De Novo Lipid Synthesis Mediated by FASN Induces Chemoresistance in Colorectal Cancer
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DOI: 10.3390/cancers15030562
Abstract: Simple Summary Resistance to oxaliplatin threatens the prognosis in of colorectal cancer (CRC). As previous studies have aroused interest in fatty acid metabolism in cancer, we determined whether fatty acid biosynthesis contribute to oxaliplatin resistance… read more here.
Keywords: oxaliplatin; crc; resistance; resistance oxaliplatin ... See more keywords