CRISPR/Cas9 Technique for Identification of Genes Regulating Oxaliplatin Resistance of Pancreatic Cancer Cell Line
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DOI: 10.1007/s12668-016-0272-3
Abstract: Genome editing approach based on prokaryotic CRISPR (clustered regularly interspaced short palindromic repeats) system is a simple and useful way to investigate gene functions on a genome-wide scale. It is especially important for cancer research… read more here.
Keywords: cell line; crispr; resistance pancreatic; pancreatic cancer ... See more keywords
Drug resistance in pancreatic cancer: New player caught in act
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DOI: 10.1016/j.ebiom.2019.02.008
Abstract: Most human cancers display high levels of heterogeneity, a feature chemotherapy [6]. The study shows that NT5C1A is strongly expressed that often impacts negatively on the response to treatments. Indeed, while radio and/or chemotherapy initially… read more here.
Keywords: drug resistance; pdac cells; pdac; resistance pancreatic ... See more keywords
LncRNA HIF1A-AS1 Promotes Gemcitabine Resistance of Pancreatic Cancer by Enhancing Glycolysis through Modulating the AKT/YB1/HIF1α Pathway
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DOI: 10.1158/0008-5472.can-21-0281
Abstract: These findings show that a reciprocal feedback of HIF1A-AS1 and HIF1α promotes gemcitabine resistance of pancreatic cancer, which provides an applicable therapeutic target. Gemcitabine (GEM) resistance is a major challenge for chemotherapy of pancreatic cancer.… read more here.
Keywords: hif1; cancer; hif1a as1; resistance pancreatic ... See more keywords
m6A Methyltransferase METTL14-Mediated Upregulation of Cytidine Deaminase Promoting Gemcitabine Resistance in Pancreatic Cancer
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DOI: 10.3389/fonc.2021.696371
Abstract: Objective Pancreatic cancer is one of the most lethal human malignancies. Gemcitabine is widely used to treat pancreatic cancer, and the resistance to chemotherapy is the major difficulty in treating the disease. N 6-methyladenosine (m6A)… read more here.
Keywords: resistance pancreatic; gemcitabine resistance; pancreatic cancer; mettl14 ... See more keywords
Macrophage C/EBPδ Drives Gemcitabine, but Not 5-FU or Paclitaxel, Resistance of Pancreatic Cancer Cells in a Deoxycytidine-Dependent Manner
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DOI: 10.3390/biomedicines10020219
Abstract: Treatment of pancreatic ductal adenocarcinoma (PDAC), a dismal disease with poor survival rates, is hampered by the high prevalence of chemotherapy resistance. Resistance is accompanied by macrophage infiltration into the tumor microenvironment, and infiltrated macrophages… read more here.
Keywords: pancreatic cancer; macrophage ebp; resistance; gemcitabine resistance ... See more keywords
EMT and Treatment Resistance in Pancreatic Cancer
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DOI: 10.3390/cancers9090122
Abstract: Pancreatic cancer (PC) is the third leading cause of adult cancer mortality in the United States. The poor prognosis for patients with PC is mainly due to its aggressive course, the limited efficacy of active… read more here.
Keywords: resistance pancreatic; pancreatic cancer; treatment resistance; resistance ... See more keywords
HNF1A regulates oxaliplatin resistance in pancreatic cancer by targeting 53BP1
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Oncology"
DOI: 10.3892/ijo.2023.5493
Abstract: DNA double-strand break repair is critically involved in oxaliplatin resistance in pancreatic ductal adenocarcinoma (PDAC). Hepatocyte nuclear factor 1 homeobox A (HNF1A) has received increased attention regarding its role in cancer progression. The present study… read more here.
Keywords: oxaliplatin resistance; resistance; hnf1a; pdac ... See more keywords