P‐Glycoprotein and Breast Cancer Resistance Protein Transporter Inhibition by Cyclosporine and Quinidine on the Pharmacokinetics of Oral Rimegepant in Healthy Subjects
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DOI: 10.1002/cpdd.1088
Abstract: Rimegepant (Nurtec ODT)—an orally administered, small‐molecule calcitonin gene–related peptide receptor antagonist indicated for the acute and preventive treatment of migraine—is a substrate for both the P‐glycoprotein and breast cancer resistance protein transporters in vitro. We… read more here.
Keywords: breast cancer; resistance protein; quinidine; cancer resistance ... See more keywords
Inhibition of Breast Cancer Resistance Protein (BCRP) by Ko143 Can Affect Pharmacokinetics of Enrofloxacin in Exopalaemon carinicauda
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Ocean University of China"
DOI: 10.1007/s11802-020-4312-9
Abstract: Adenosine triphosphate-binding cassette transporter breast cancer resistance protein (BCRP) exists highly in the apical membranes of epithelia, and is involved in drug availability. Ko143 is a typical inhibitor of BCRP in rodents. The synthetic antibacterial… read more here.
Keywords: cancer resistance; resistance protein; breast cancer; exopalaemon carinicauda ... See more keywords
Multidrug resistance protein 4 (MRP4) is expressed as transcript variants in both Gallus domesticus and Gyps himalyanesis.
Sign Up to like & getrecommendations! Published in 2019 at "Gene"
DOI: 10.1016/j.gene.2018.12.014
Abstract: The non-steroidal anti-inflammatory drug (NSAID) diclofenac, known to cause hyperuricemia and concomitant visceral gout in Gyps vultures is suggested to be a result of interference with renal uric acid excretion. Three species of Gyps vultures… read more here.
Keywords: resistance protein; diclofenac; gallus domesticus; multidrug resistance ... See more keywords
Correlation Analysis of Potential Breast Cancer Resistance Protein Probes in Different Monolayer Systems.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2018.07.014
Abstract: Breast cancer resistance protein (BCRP) is a point of interest in drug-drug interaction safety testing. Therefore, a consensus probe that can be applied as victim in multiple experimental settings is of great benefit. Identification of… read more here.
Keywords: resistance protein; cancer resistance; breast cancer;
Effect of capsaicin on breast cancer resistance protein (BCRP/Abcg2) and pharmacokinetics of probe substrates in rats
Sign Up to like & getrecommendations! Published in 2022 at "Xenobiotica"
DOI: 10.1080/00498254.2021.2025281
Abstract: Abstract Breast cancer resistance protein (BCRP/Abcg2 in human, Bcrp/Abcg2 in rat), a member of the ATP-binding cassette (ABC) transporter family, acts as an efflux pump for xenobiotics, with ability to transport various drugs out of… read more here.
Keywords: protein bcrp; breast cancer; bcrp abcg2; cancer resistance ... See more keywords
Symptomatic myopathies in sarcoidosis: disease spectrum and Myxovirus resistance protein A (MxA) expression.
Sign Up to like & getrecommendations! Published in 2022 at "Rheumatology"
DOI: 10.1093/rheumatology/keac668
Abstract: OBJECTIVES Symptomatic myopathy in sarcoidosis patients is not always due to sarcoid myopathy (SM). We investigated the clinical and pathological spectrum including myxovirus resistance protein A (MxA) expression among sarcoidosis patients. METHODS We reviewed the… read more here.
Keywords: sarcoidosis; mxa expression; myxovirus resistance; sarcoidosis patients ... See more keywords
Regulation of breast cancer resistance protein and P‐glycoprotein by ezrin, radixin and moesin in lung, intestinal and renal cancer cell lines
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Pharmacy and Pharmacology"
DOI: 10.1111/jphp.13225
Abstract: Ezrin (Ezr), radixin (Rdx) and moesin (Msn) (ERM) proteins anchor other proteins to the cell membrane, serving to regulate their localization and function. Here, we examined whether ERM proteins functionally regulate breast cancer resistance protein… read more here.
Keywords: cancer resistance; resistance protein; cell lines; lung intestinal ... See more keywords
Bioengineering nisin to overcome the nisin resistance protein
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DOI: 10.1111/mmi.14183
Abstract: The emergence and dissemination of antibiotic resistant bacteria is a major medical challenge. Lantibiotics are highly modified bacterially produced antimicrobial peptides that have attracted considerable interest as alternatives or adjuncts to existing antibiotics. Nisin, the… read more here.
Keywords: bioengineering nisin; nisin; resistance protein; resistance ... See more keywords
Epigenetic Regulation of Multidrug Resistance Protein 1 and Breast Cancer Resistance Protein Transporters by Histone Deacetylase Inhibition
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DOI: 10.1124/dmd.119.089953
Abstract: Multidrug resistance protein 1 (MDR1, ABCB1, P-glycoprotein) and breast cancer resistance protein (BCRP, ABCG2) are key efflux transporters that mediate the extrusion of drugs and toxicants in cancer cells and healthy tissues including the liver,… read more here.
Keywords: mdr1 bcrp; cancer; resistance; inhibition ... See more keywords
Peroxynitrite and 4-Hydroxynonenal Inactivate Breast Cancer Resistance Protein/ABCG2
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DOI: 10.1155/2019/3891535
Abstract: Oxidative stress may arise from a variety of pathologies and results in the formation of toxic and reactive chemical species. Extensive research has been done to establish mechanisms of formation and cytotoxic effects of a… read more here.
Keywords: inactivate breast; cancer resistance; resistance protein; hydroxynonenal inactivate ... See more keywords
Differential expression of breast cancer-resistance protein, lung resistance protein, and multidrug resistance protein 1 in retinas of streptozotocin-induced diabetic mice.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of ophthalmology"
DOI: 10.18240/ijo.2017.04.03
Abstract: AIM To investigate the altering expression profiles of efflux transporters such as breast cancer-resistance protein (BCRP), lung resistance protein (LRP), and multidrug resistance protein 1 (MDR1) at the inner blood-retinal barrier (BRB) during the development… read more here.
Keywords: protein; mice; expression profiles; resistance protein ... See more keywords