Polycomb complex protein BMI1 confers resistance to tamoxifen in estrogen receptor positive breast cancer.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer letters"
DOI: 10.1016/j.canlet.2018.03.048
Abstract: We report that BMI1 promotes tamoxifen resistance in estrogen receptor (ER)-positive breast cancer (BC). BMI1 overexpression conferred MCF7 and TD47 cells resistance to tamoxifen; BMI1 knockdown sensitized the process. In MCF7-derived tamoxifen resistant cells, BMI1 expression… read more here.
Keywords: resistance tamoxifen; estrogen receptor; bmi1; cancer ... See more keywords
Bioinformatic Study of Involved Mechanisms in Relapse and Drug Resistance of Tamoxifen-Treated Breast Cancer.
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DOI: 10.2174/1871520620666201029114253
Abstract: BACKGROUND Breast cancer is currently among the most common cause of mortality in women. Estrogen and its subsequent signaling pathways play an important role in the occurrence of breast cancer relapse. Tamoxifen is the most… read more here.
Keywords: cancer; resistance; resistance tamoxifen; breast cancer ... See more keywords