Overcoming Resistance to Targeted Anticancer Therapies through Small-Molecule-Mediated MEK Degradation.
Sign Up to like & getrecommendations! Published in 2018 at "Cell chemical biology"
DOI: 10.1016/j.chembiol.2018.05.008
Abstract: The discovery of mutant or fusion kinases that drive oncogenesis, and the subsequent approval of specific inhibitors for these enzymes, has been instrumental in the management of some cancers. However, acquired resistance remains a significant… read more here.
Keywords: degradation; anticancer therapies; resistance targeted; resistance ... See more keywords
Epigenetic Alterations and Mechanisms That Drive Resistance to Targeted Cancer Therapies
Sign Up to like & getrecommendations! Published in 2021 at "Cancer Research"
DOI: 10.1158/0008-5472.can-21-1606
Abstract: Cancer is a complex disease and cancer cells typically harbor multiple genetic and epigenetic alterations. Large-scale sequencing of patient-derived cancer samples has identified several druggable driver oncogenes. Many of these oncogenes can be pharmacologically targeted… read more here.
Keywords: cancer types; resistance targeted; cancer; resistance ... See more keywords
Adaptive Mutability May Underlie Some Resistance to Targeted Therapies.
Sign Up to like & getrecommendations! Published in 2020 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-rw2019-173
Abstract: Colorectal cancer cells react to targeted therapies by transiently increasing their mutation rate. read more here.
Keywords: underlie resistance; may underlie; resistance targeted; targeted therapies ... See more keywords
Overcoming resistance to targeted therapies in chronic lymphocytic leukemia.
Sign Up to like & getrecommendations! Published in 2021 at "Blood advances"
DOI: 10.1182/bloodadvances.2020003423
Abstract: Insight into the critical role of B-cell receptor signaling for the pathogenesis of chronic lymphocytic leukemia (CLL) led to the development of targeted therapies directed at key regulators of cell survival. Agents targeting B-cell lymphoma-2… read more here.
Keywords: lymphocytic leukemia; resistance targeted; resistance; chronic lymphocytic ... See more keywords
Overcoming resistance to targeted therapy with immunotherapy and combination therapy for metastatic melanoma.
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.18523
Abstract: Resistance to targeted therapy is an ongoing problem for the successful treatment of Stage IV metastatic melanoma. For many patients, the use of targeted therapies, such as BRAF kinase inhibitors, were initially promising yet resistance… read more here.
Keywords: combination; immunotherapy; resistance targeted; metastatic melanoma ... See more keywords