Electrostatic lock in the transport cycle of the multidrug resistance transporter EmrE
Sign Up to like & getrecommendations! Published in 2018 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1722399115
Abstract: Significance EmrE is a small membrane transporter found in Escherichia coli that exports drug-like molecules from the cell, contributing to antibiotic resistance. In EmrE, as well as in the wider small-multidrug resistance transporter family, a… read more here.
Keywords: microscopy; transport; resistance transporter; resistance ... See more keywords
The Knock-Down of the Chloroquine Resistance Transporter PfCRT Is Linked to Oligopeptide Handling in Plasmodium falciparum
Sign Up to like & getrecommendations! Published in 2022 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.01101-22
Abstract: The chloroquine resistance transporter, PfCRT, is important for the survival of the human malaria parasite Plasmodium falciparum. It increases the tolerance to many antimalarial drugs, and it is essential for the development of the parasite… read more here.
Keywords: chloroquine resistance; falciparum; resistance; pfcrt ... See more keywords
No Plasmodium falciparum Chloroquine Resistance Transporter and Artemisinin Resistance Mutations, Haiti
Sign Up to like & getrecommendations! Published in 2018 at "Emerging Infectious Diseases"
DOI: 10.3201/eid2411.180738
Abstract: We obtained 78 human blood samples from areas in Haiti with high transmission of malaria and found no drug resistance–associated mutations in Plasmodium falciparum chloroquine resistance transporter and Kelch 13 genes. We recommend maintaining chloroquine… read more here.
Keywords: falciparum chloroquine; resistance transporter; chloroquine resistance; plasmodium falciparum ... See more keywords