Targeting AraC-Resistant Acute Myeloid Leukemia by Dual Inhibition of CDK9 and Bcl-2: A Systematic Review and Meta-Analysis
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DOI: 10.1155/2022/2842066
Abstract: Purpose This study aims to determine the influence of targeting araC-resistant acute myeloid leukemia by dual inhibition cyclin-dependent protein kinase (CDK9) and B-cell lymphoma-2 （Bcl-2). Method The c-Myc inhibitor 10058-F4 and the CDK9 inhibitor AZD4573… read more here.
Keywords: myeloid leukemia; resistant acute; cdk9; targeting arac ... See more keywords
Combination Therapy for Treating Advanced Drug-Resistant Acute Lymphoblastic Leukemia
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DOI: 10.1158/2326-6066.cir-19-0058
Abstract: Blocking BAFF-R early in ALL promotes killing of leukemic cells. However, if given at later disease stages, efficacy is limited due to TGFβ. Combining VAY736 and a TGFβR1 inhibitor improved treatment efficacy in advanced and… read more here.
Keywords: acute lymphoblastic; drug resistant; drug; resistant acute ... See more keywords